Dilated left atrium and pulmonary veins in patients with calcified coronary artery: A potential contributor to the genesis of atrial fibrillation

Nan Hung Pan, Hsuan Ming Tsao, Nen Chung Chang, Chih Ming Lee, Yi Jen Chen, Shih Ann Chen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Ischemic Remodeling of Left Atrium and Pulmonary Vein. Introduction: Coronary artery disease (CAD) is an important etiology of atrial fibrillation (AF). Coronary artery calcification is a marker of coronary atherosclerosis and coronary events. The purpose of this study was to investigate whether larger left atrium (LA) and pulmonary veins (PVs) were seen by multidetector computed tomography (MDCT) scans in those patients with higher coronary calcium scores. Methods and Results: A total of 166 patients undergoing MDCT for general check-up (n = 128, 77%) or suspected CAD (n = 38, 23%) were enrolled and divided into a control (calcium score = 0, n = 60), medium calcium score (calcium score = 100∼400, n = 47), and high calcium score (calcium score >400, n = 59) groups. Diameters and areas of the LA, left atrial appendage (LAA), and PVs were measured by MDCT. The high calcium score group had significantly larger PVs diameters, LAA orifice area (1.9 ± 1.4 cm 2, 0.9 ± 0.5 cm 2, 0.8 ± 0.4 cm 2, P <0.005), LA anterior-posterior distance (32.2 ± 6.8 mm, 30.4 ± 6.5 mm, 27.3 ± 6.0 mm, P <0.05), and transverse distance (52.6 ± 7.3 mm, 50.2 ± 9 mm, 49.5 ± 4.6 mm, P <0.05) than the medium calcium score and control groups. Six (3.6%) patients with paroxysmal AF had higher calcium scores and larger diameters of LA, LAA, and PVs than those (96.4%) without paroxysmal AF. Two patients in the high calcium score group had calcified PVs localized to the right upper and left upper PVs. The incidence of calcified PVs was 1.2% for the total patients and 3.3% for the high calcium score patients. Conclusion: In the presence of high calcium scores in this patient population, the LA, LAA, and PVs were enlarged.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalJournal of Cardiovascular Electrophysiology
Volume20
Issue number2
DOIs
Publication statusPublished - Feb 2009

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Pulmonary Veins
Heart Atria
Atrial Fibrillation
Coronary Vessels
Calcium
Atrial Appendage
Multidetector Computed Tomography
Coronary Artery Disease

Keywords

  • Atrial fibrillation
  • Coronary artery calcification
  • Pulmonary vein

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Dilated left atrium and pulmonary veins in patients with calcified coronary artery : A potential contributor to the genesis of atrial fibrillation. / Pan, Nan Hung; Tsao, Hsuan Ming; Chang, Nen Chung; Lee, Chih Ming; Chen, Yi Jen; Chen, Shih Ann.

In: Journal of Cardiovascular Electrophysiology, Vol. 20, No. 2, 02.2009, p. 153-158.

Research output: Contribution to journalArticle

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abstract = "Ischemic Remodeling of Left Atrium and Pulmonary Vein. Introduction: Coronary artery disease (CAD) is an important etiology of atrial fibrillation (AF). Coronary artery calcification is a marker of coronary atherosclerosis and coronary events. The purpose of this study was to investigate whether larger left atrium (LA) and pulmonary veins (PVs) were seen by multidetector computed tomography (MDCT) scans in those patients with higher coronary calcium scores. Methods and Results: A total of 166 patients undergoing MDCT for general check-up (n = 128, 77{\%}) or suspected CAD (n = 38, 23{\%}) were enrolled and divided into a control (calcium score = 0, n = 60), medium calcium score (calcium score = 100∼400, n = 47), and high calcium score (calcium score >400, n = 59) groups. Diameters and areas of the LA, left atrial appendage (LAA), and PVs were measured by MDCT. The high calcium score group had significantly larger PVs diameters, LAA orifice area (1.9 ± 1.4 cm 2, 0.9 ± 0.5 cm 2, 0.8 ± 0.4 cm 2, P <0.005), LA anterior-posterior distance (32.2 ± 6.8 mm, 30.4 ± 6.5 mm, 27.3 ± 6.0 mm, P <0.05), and transverse distance (52.6 ± 7.3 mm, 50.2 ± 9 mm, 49.5 ± 4.6 mm, P <0.05) than the medium calcium score and control groups. Six (3.6{\%}) patients with paroxysmal AF had higher calcium scores and larger diameters of LA, LAA, and PVs than those (96.4{\%}) without paroxysmal AF. Two patients in the high calcium score group had calcified PVs localized to the right upper and left upper PVs. The incidence of calcified PVs was 1.2{\%} for the total patients and 3.3{\%} for the high calcium score patients. Conclusion: In the presence of high calcium scores in this patient population, the LA, LAA, and PVs were enlarged.",
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T2 - A potential contributor to the genesis of atrial fibrillation

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AU - Lee, Chih Ming

AU - Chen, Yi Jen

AU - Chen, Shih Ann

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N2 - Ischemic Remodeling of Left Atrium and Pulmonary Vein. Introduction: Coronary artery disease (CAD) is an important etiology of atrial fibrillation (AF). Coronary artery calcification is a marker of coronary atherosclerosis and coronary events. The purpose of this study was to investigate whether larger left atrium (LA) and pulmonary veins (PVs) were seen by multidetector computed tomography (MDCT) scans in those patients with higher coronary calcium scores. Methods and Results: A total of 166 patients undergoing MDCT for general check-up (n = 128, 77%) or suspected CAD (n = 38, 23%) were enrolled and divided into a control (calcium score = 0, n = 60), medium calcium score (calcium score = 100∼400, n = 47), and high calcium score (calcium score >400, n = 59) groups. Diameters and areas of the LA, left atrial appendage (LAA), and PVs were measured by MDCT. The high calcium score group had significantly larger PVs diameters, LAA orifice area (1.9 ± 1.4 cm 2, 0.9 ± 0.5 cm 2, 0.8 ± 0.4 cm 2, P <0.005), LA anterior-posterior distance (32.2 ± 6.8 mm, 30.4 ± 6.5 mm, 27.3 ± 6.0 mm, P <0.05), and transverse distance (52.6 ± 7.3 mm, 50.2 ± 9 mm, 49.5 ± 4.6 mm, P <0.05) than the medium calcium score and control groups. Six (3.6%) patients with paroxysmal AF had higher calcium scores and larger diameters of LA, LAA, and PVs than those (96.4%) without paroxysmal AF. Two patients in the high calcium score group had calcified PVs localized to the right upper and left upper PVs. The incidence of calcified PVs was 1.2% for the total patients and 3.3% for the high calcium score patients. Conclusion: In the presence of high calcium scores in this patient population, the LA, LAA, and PVs were enlarged.

AB - Ischemic Remodeling of Left Atrium and Pulmonary Vein. Introduction: Coronary artery disease (CAD) is an important etiology of atrial fibrillation (AF). Coronary artery calcification is a marker of coronary atherosclerosis and coronary events. The purpose of this study was to investigate whether larger left atrium (LA) and pulmonary veins (PVs) were seen by multidetector computed tomography (MDCT) scans in those patients with higher coronary calcium scores. Methods and Results: A total of 166 patients undergoing MDCT for general check-up (n = 128, 77%) or suspected CAD (n = 38, 23%) were enrolled and divided into a control (calcium score = 0, n = 60), medium calcium score (calcium score = 100∼400, n = 47), and high calcium score (calcium score >400, n = 59) groups. Diameters and areas of the LA, left atrial appendage (LAA), and PVs were measured by MDCT. The high calcium score group had significantly larger PVs diameters, LAA orifice area (1.9 ± 1.4 cm 2, 0.9 ± 0.5 cm 2, 0.8 ± 0.4 cm 2, P <0.005), LA anterior-posterior distance (32.2 ± 6.8 mm, 30.4 ± 6.5 mm, 27.3 ± 6.0 mm, P <0.05), and transverse distance (52.6 ± 7.3 mm, 50.2 ± 9 mm, 49.5 ± 4.6 mm, P <0.05) than the medium calcium score and control groups. Six (3.6%) patients with paroxysmal AF had higher calcium scores and larger diameters of LA, LAA, and PVs than those (96.4%) without paroxysmal AF. Two patients in the high calcium score group had calcified PVs localized to the right upper and left upper PVs. The incidence of calcified PVs was 1.2% for the total patients and 3.3% for the high calcium score patients. Conclusion: In the presence of high calcium scores in this patient population, the LA, LAA, and PVs were enlarged.

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