Dilated Cardiomyopathy After Long-Term Right Ventricular Apical Pacing in Children With Complete Atrioventricular Block: Role of Setting of Ventricular Pacing

Chun An Chen, Jou Kou Wang, Ming Tai Lin, Chun Wei Lu, Kun Lang Wu, Shuenn Nan Chiu, Hsin Hui Chiu, En Ting Wu, Hung Chi Lue, Mei Hwan Wu

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6 Citations (Scopus)


Background: Pediatric patients paced for complete atrioventricular block (CAVB) are at risk of developing dilated cardiomyopathy (DCM). We sought to explore the role played by the setting of ventricular pacing. Methods and Results: A total of 35 patients 90% in all patients. Multivariate analysis revealed that the cumulative Z score of lower ventricular rate setting was the single most important risk factor for DCM (HR, 3.14; 95% CI, 1.07-9.19; P = .037). Subgroup analysis in patients with VVI/VVIR modes revealed an even stronger predictive value of the cumulative Z score of lower ventricular rate setting (HR, 9.12; 95% CI, 1.53-54.24; P = .015). Conclusions: Higher setting of the lower ventricular rate, though still within the age-appropriate range, was associated with increased risk of developing DCM in pediatric patients with CAVB and chronic RV apical pacing.

Original languageEnglish
Pages (from-to)681-688
Number of pages8
JournalJournal of Cardiac Failure
Issue number8
Publication statusPublished - Oct 2009
Externally publishedYes



  • Complete atrioventricular block
  • dilated cardiomyopathy
  • pacemakers
  • right ventricular apical pacing

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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