Dilated Cardiomyopathy After Long-Term Right Ventricular Apical Pacing in Children With Complete Atrioventricular Block: Role of Setting of Ventricular Pacing

Chun An Chen, Jou Kou Wang, Ming Tai Lin, Chun Wei Lu, Kun Lang Wu, Shuenn Nan Chiu, Hsin Hui Chiu, En Ting Wu, Hung Chi Lue, Mei Hwan Wu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Pediatric patients paced for complete atrioventricular block (CAVB) are at risk of developing dilated cardiomyopathy (DCM). We sought to explore the role played by the setting of ventricular pacing. Methods and Results: A total of 35 patients 90% in all patients. Multivariate analysis revealed that the cumulative Z score of lower ventricular rate setting was the single most important risk factor for DCM (HR, 3.14; 95% CI, 1.07-9.19; P = .037). Subgroup analysis in patients with VVI/VVIR modes revealed an even stronger predictive value of the cumulative Z score of lower ventricular rate setting (HR, 9.12; 95% CI, 1.53-54.24; P = .015). Conclusions: Higher setting of the lower ventricular rate, though still within the age-appropriate range, was associated with increased risk of developing DCM in pediatric patients with CAVB and chronic RV apical pacing.

Original languageEnglish
Pages (from-to)681-688
Number of pages8
JournalJournal of Cardiac Failure
Volume15
Issue number8
DOIs
Publication statusPublished - Oct 2009
Externally publishedYes

Fingerprint

Atrioventricular Block
Dilated Cardiomyopathy
Pediatrics
Multivariate Analysis

Keywords

  • Complete atrioventricular block
  • dilated cardiomyopathy
  • pacemakers
  • right ventricular apical pacing

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Dilated Cardiomyopathy After Long-Term Right Ventricular Apical Pacing in Children With Complete Atrioventricular Block : Role of Setting of Ventricular Pacing. / Chen, Chun An; Wang, Jou Kou; Lin, Ming Tai; Lu, Chun Wei; Wu, Kun Lang; Chiu, Shuenn Nan; Chiu, Hsin Hui; Wu, En Ting; Lue, Hung Chi; Wu, Mei Hwan.

In: Journal of Cardiac Failure, Vol. 15, No. 8, 10.2009, p. 681-688.

Research output: Contribution to journalArticle

Chen, Chun An ; Wang, Jou Kou ; Lin, Ming Tai ; Lu, Chun Wei ; Wu, Kun Lang ; Chiu, Shuenn Nan ; Chiu, Hsin Hui ; Wu, En Ting ; Lue, Hung Chi ; Wu, Mei Hwan. / Dilated Cardiomyopathy After Long-Term Right Ventricular Apical Pacing in Children With Complete Atrioventricular Block : Role of Setting of Ventricular Pacing. In: Journal of Cardiac Failure. 2009 ; Vol. 15, No. 8. pp. 681-688.
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abstract = "Background: Pediatric patients paced for complete atrioventricular block (CAVB) are at risk of developing dilated cardiomyopathy (DCM). We sought to explore the role played by the setting of ventricular pacing. Methods and Results: A total of 35 patients 90{\%} in all patients. Multivariate analysis revealed that the cumulative Z score of lower ventricular rate setting was the single most important risk factor for DCM (HR, 3.14; 95{\%} CI, 1.07-9.19; P = .037). Subgroup analysis in patients with VVI/VVIR modes revealed an even stronger predictive value of the cumulative Z score of lower ventricular rate setting (HR, 9.12; 95{\%} CI, 1.53-54.24; P = .015). Conclusions: Higher setting of the lower ventricular rate, though still within the age-appropriate range, was associated with increased risk of developing DCM in pediatric patients with CAVB and chronic RV apical pacing.",
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AU - Lu, Chun Wei

AU - Wu, Kun Lang

AU - Chiu, Shuenn Nan

AU - Chiu, Hsin Hui

AU - Wu, En Ting

AU - Lue, Hung Chi

AU - Wu, Mei Hwan

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N2 - Background: Pediatric patients paced for complete atrioventricular block (CAVB) are at risk of developing dilated cardiomyopathy (DCM). We sought to explore the role played by the setting of ventricular pacing. Methods and Results: A total of 35 patients 90% in all patients. Multivariate analysis revealed that the cumulative Z score of lower ventricular rate setting was the single most important risk factor for DCM (HR, 3.14; 95% CI, 1.07-9.19; P = .037). Subgroup analysis in patients with VVI/VVIR modes revealed an even stronger predictive value of the cumulative Z score of lower ventricular rate setting (HR, 9.12; 95% CI, 1.53-54.24; P = .015). Conclusions: Higher setting of the lower ventricular rate, though still within the age-appropriate range, was associated with increased risk of developing DCM in pediatric patients with CAVB and chronic RV apical pacing.

AB - Background: Pediatric patients paced for complete atrioventricular block (CAVB) are at risk of developing dilated cardiomyopathy (DCM). We sought to explore the role played by the setting of ventricular pacing. Methods and Results: A total of 35 patients 90% in all patients. Multivariate analysis revealed that the cumulative Z score of lower ventricular rate setting was the single most important risk factor for DCM (HR, 3.14; 95% CI, 1.07-9.19; P = .037). Subgroup analysis in patients with VVI/VVIR modes revealed an even stronger predictive value of the cumulative Z score of lower ventricular rate setting (HR, 9.12; 95% CI, 1.53-54.24; P = .015). Conclusions: Higher setting of the lower ventricular rate, though still within the age-appropriate range, was associated with increased risk of developing DCM in pediatric patients with CAVB and chronic RV apical pacing.

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