Diffusion-tensor MR imaging for evaluation of the efficacy of hyperbaric oxygen therapy in patients with delayed neuropsychiatric syndrome caused by carbon monoxide inhalation

C. P. Lo, S. Y. Chen, M. C. Chou, C. Y. Wang, K. W. Lee, C. J. Hsueh, C. Y. Chen, K. L. Huang, G. S. Huang

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The purpose of this study is to assess the efficacy of hyperbaric oxygen therapy (HBOT) in patients with delayed neuropsychiatric syndrome (DNS) caused by carbon monoxide (CO) inhalation using diffusion tensor magnetic resonance (MR) imaging and neuropsychological test. Conventional and diffusion tensor brain MR imaging exams were performed in six patients with DNS immediately before and 3 months after the HBOT to obtain fractional anisotropy (FA) values. Six age- and sex-matched normal control subjects also received MR exams for comparison. Mini-Mental State Examination (MMSE) was also performed in patients immediately before and 3 months after the HBOT. A significantly higher mean FA value was found in control subjects as compared with the patients both before and 3 months after the HBOT (P <0.001). The mean FA value 3 months after the HBOT was also significantly higher than that before the HBOT in the patient group (P <0.001). All of the patients regained full scores in the MMSE 3 months after the HBOT. Diffusion tensor MR imaging can be a quantitative method for the assessment of the white matter change and monitor the treatment response in patients of CO-induced DNS with a good clinical correlation. HBO may be an effective therapy for DNS.

Original languageEnglish
Pages (from-to)777-782
Number of pages6
JournalEuropean Journal of Neurology
Volume14
Issue number7
DOIs
Publication statusPublished - Jul 2007
Externally publishedYes

Fingerprint

Hyperbaric Oxygenation
Diffusion Magnetic Resonance Imaging
Carbon Monoxide
Inhalation
Anisotropy
Neuropsychological Tests
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Brain
Therapeutics

Keywords

  • Brain
  • Carbon monoxide
  • Delayed neuropsychiatric syndrome
  • Diffusion-tensor MRI
  • Hyperbaric oxygen

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Diffusion-tensor MR imaging for evaluation of the efficacy of hyperbaric oxygen therapy in patients with delayed neuropsychiatric syndrome caused by carbon monoxide inhalation. / Lo, C. P.; Chen, S. Y.; Chou, M. C.; Wang, C. Y.; Lee, K. W.; Hsueh, C. J.; Chen, C. Y.; Huang, K. L.; Huang, G. S.

In: European Journal of Neurology, Vol. 14, No. 7, 07.2007, p. 777-782.

Research output: Contribution to journalArticle

Lo, C. P. ; Chen, S. Y. ; Chou, M. C. ; Wang, C. Y. ; Lee, K. W. ; Hsueh, C. J. ; Chen, C. Y. ; Huang, K. L. ; Huang, G. S. / Diffusion-tensor MR imaging for evaluation of the efficacy of hyperbaric oxygen therapy in patients with delayed neuropsychiatric syndrome caused by carbon monoxide inhalation. In: European Journal of Neurology. 2007 ; Vol. 14, No. 7. pp. 777-782.
@article{f2ccf79712bd4b888b028293b369e33a,
title = "Diffusion-tensor MR imaging for evaluation of the efficacy of hyperbaric oxygen therapy in patients with delayed neuropsychiatric syndrome caused by carbon monoxide inhalation",
abstract = "The purpose of this study is to assess the efficacy of hyperbaric oxygen therapy (HBOT) in patients with delayed neuropsychiatric syndrome (DNS) caused by carbon monoxide (CO) inhalation using diffusion tensor magnetic resonance (MR) imaging and neuropsychological test. Conventional and diffusion tensor brain MR imaging exams were performed in six patients with DNS immediately before and 3 months after the HBOT to obtain fractional anisotropy (FA) values. Six age- and sex-matched normal control subjects also received MR exams for comparison. Mini-Mental State Examination (MMSE) was also performed in patients immediately before and 3 months after the HBOT. A significantly higher mean FA value was found in control subjects as compared with the patients both before and 3 months after the HBOT (P <0.001). The mean FA value 3 months after the HBOT was also significantly higher than that before the HBOT in the patient group (P <0.001). All of the patients regained full scores in the MMSE 3 months after the HBOT. Diffusion tensor MR imaging can be a quantitative method for the assessment of the white matter change and monitor the treatment response in patients of CO-induced DNS with a good clinical correlation. HBO may be an effective therapy for DNS.",
keywords = "Brain, Carbon monoxide, Delayed neuropsychiatric syndrome, Diffusion-tensor MRI, Hyperbaric oxygen",
author = "Lo, {C. P.} and Chen, {S. Y.} and Chou, {M. C.} and Wang, {C. Y.} and Lee, {K. W.} and Hsueh, {C. J.} and Chen, {C. Y.} and Huang, {K. L.} and Huang, {G. S.}",
year = "2007",
month = "7",
doi = "10.1111/j.1468-1331.2007.01854.x",
language = "English",
volume = "14",
pages = "777--782",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Diffusion-tensor MR imaging for evaluation of the efficacy of hyperbaric oxygen therapy in patients with delayed neuropsychiatric syndrome caused by carbon monoxide inhalation

AU - Lo, C. P.

AU - Chen, S. Y.

AU - Chou, M. C.

AU - Wang, C. Y.

AU - Lee, K. W.

AU - Hsueh, C. J.

AU - Chen, C. Y.

AU - Huang, K. L.

AU - Huang, G. S.

PY - 2007/7

Y1 - 2007/7

N2 - The purpose of this study is to assess the efficacy of hyperbaric oxygen therapy (HBOT) in patients with delayed neuropsychiatric syndrome (DNS) caused by carbon monoxide (CO) inhalation using diffusion tensor magnetic resonance (MR) imaging and neuropsychological test. Conventional and diffusion tensor brain MR imaging exams were performed in six patients with DNS immediately before and 3 months after the HBOT to obtain fractional anisotropy (FA) values. Six age- and sex-matched normal control subjects also received MR exams for comparison. Mini-Mental State Examination (MMSE) was also performed in patients immediately before and 3 months after the HBOT. A significantly higher mean FA value was found in control subjects as compared with the patients both before and 3 months after the HBOT (P <0.001). The mean FA value 3 months after the HBOT was also significantly higher than that before the HBOT in the patient group (P <0.001). All of the patients regained full scores in the MMSE 3 months after the HBOT. Diffusion tensor MR imaging can be a quantitative method for the assessment of the white matter change and monitor the treatment response in patients of CO-induced DNS with a good clinical correlation. HBO may be an effective therapy for DNS.

AB - The purpose of this study is to assess the efficacy of hyperbaric oxygen therapy (HBOT) in patients with delayed neuropsychiatric syndrome (DNS) caused by carbon monoxide (CO) inhalation using diffusion tensor magnetic resonance (MR) imaging and neuropsychological test. Conventional and diffusion tensor brain MR imaging exams were performed in six patients with DNS immediately before and 3 months after the HBOT to obtain fractional anisotropy (FA) values. Six age- and sex-matched normal control subjects also received MR exams for comparison. Mini-Mental State Examination (MMSE) was also performed in patients immediately before and 3 months after the HBOT. A significantly higher mean FA value was found in control subjects as compared with the patients both before and 3 months after the HBOT (P <0.001). The mean FA value 3 months after the HBOT was also significantly higher than that before the HBOT in the patient group (P <0.001). All of the patients regained full scores in the MMSE 3 months after the HBOT. Diffusion tensor MR imaging can be a quantitative method for the assessment of the white matter change and monitor the treatment response in patients of CO-induced DNS with a good clinical correlation. HBO may be an effective therapy for DNS.

KW - Brain

KW - Carbon monoxide

KW - Delayed neuropsychiatric syndrome

KW - Diffusion-tensor MRI

KW - Hyperbaric oxygen

UR - http://www.scopus.com/inward/record.url?scp=34347324102&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34347324102&partnerID=8YFLogxK

U2 - 10.1111/j.1468-1331.2007.01854.x

DO - 10.1111/j.1468-1331.2007.01854.x

M3 - Article

C2 - 17594334

AN - SCOPUS:34347324102

VL - 14

SP - 777

EP - 782

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 7

ER -