Diffusion-tensor MR imaging for evaluation of the efficacy of hyperbaric oxygen therapy in patients with delayed neuropsychiatric syndrome caused by carbon monoxide inhalation

C. P. Lo, S. Y. Chen, M. C. Chou, C. Y. Wang, K. W. Lee, C. J. Hsueh, C. Y. Chen, K. L. Huang, G. S. Huang

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

The purpose of this study is to assess the efficacy of hyperbaric oxygen therapy (HBOT) in patients with delayed neuropsychiatric syndrome (DNS) caused by carbon monoxide (CO) inhalation using diffusion tensor magnetic resonance (MR) imaging and neuropsychological test. Conventional and diffusion tensor brain MR imaging exams were performed in six patients with DNS immediately before and 3 months after the HBOT to obtain fractional anisotropy (FA) values. Six age- and sex-matched normal control subjects also received MR exams for comparison. Mini-Mental State Examination (MMSE) was also performed in patients immediately before and 3 months after the HBOT. A significantly higher mean FA value was found in control subjects as compared with the patients both before and 3 months after the HBOT (P <0.001). The mean FA value 3 months after the HBOT was also significantly higher than that before the HBOT in the patient group (P <0.001). All of the patients regained full scores in the MMSE 3 months after the HBOT. Diffusion tensor MR imaging can be a quantitative method for the assessment of the white matter change and monitor the treatment response in patients of CO-induced DNS with a good clinical correlation. HBO may be an effective therapy for DNS.

Original languageEnglish
Pages (from-to)777-782
Number of pages6
JournalEuropean Journal of Neurology
Volume14
Issue number7
DOIs
Publication statusPublished - Jul 2007
Externally publishedYes

Keywords

  • Brain
  • Carbon monoxide
  • Delayed neuropsychiatric syndrome
  • Diffusion-tensor MRI
  • Hyperbaric oxygen

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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