Diffusion tensor magnetic resonance imaging mapping the fiber architecture remodeling in human myocardium after infarction: Correlation with viability and wall motion

Ming Ting Wu, Wen Yih I Tseng, Mao Yuan M Su, Chun Peng Liu, Kuan Rau Chiou, Van J. Wedeen, Timothy G. Reese, Chien Fang Yang

Research output: Contribution to journalArticle

188 Citations (Scopus)

Abstract

BACKGROUND - Diffusion tensor magnetic resonance imaging (DT-MRI) provides a means for nondestructive characterization of myocardial architecture. We used DT-MRI to investigate changes in direction-dependent water diffusivity to reflect alterations in tissue integrity (trace apparent diffusion coefficients [ADCs] and fractional anisotropy [FA]), as well as indicators of remodeling of fiber helix angles, in patients after myocardial infarction. METHODS AND RESULTS - Thirty-seven patients (35 men, 2 women; median age, 59) after acute myocardial infarction (median interval from onset, 26 days) were enrolled. DT-MRI was performed at the midventricular level to measure trace ADC, FA, and helix angles of myofibers. Helix angles were grouped into left-handed helical fibers, circumferential fibers, and right-handed helical fibers. Measurements were correlated with viability and regional wall motion assessed by contrast-delay-enhancement and cine MRI, respectively. The infarct zone showed significantly increased trace ADC and decreased FA than the remote zone. The percentage of left-handed helical fibers increased from the remote zone (mean±SD, 13.3±5.8%) to the adjacent zone (19.2±9.7%) and infarct zone (25.8±18.4%) (MANOVA, P=0.004). The percentage of right-handed helical fibers decreased from the remote zone (35.0±9.0%) to the adjacent zone (25.5±11.5%) and infarct zone (15.9±9.2%) (P<0.001). Multiple linear regression showed that the percentage of left-handed helical fibers of the infarct zone was the strongest correlate of infarct size and predictor of ejection fraction. CONCLUSIONS - In vivo DT-MRI of postinfarct myocardium revealed a significant increase in trace ADC and a decrease in FA, indicating altered tissue integrity. The redistribution of fiber architecture correlated with infarct size and left ventricular function. This technique may help us understand structural correlates of functional remodeling after infarction.

Original languageEnglish
Pages (from-to)1036-1045
Number of pages10
JournalCirculation
Volume114
Issue number10
DOIs
Publication statusPublished - Sep 1 2006
Externally publishedYes

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Diffusion Magnetic Resonance Imaging
Anisotropy
Infarction
Myocardium
Myocardial Infarction
Cine Magnetic Resonance Imaging
Left Ventricular Function
Linear Models
Water

Keywords

  • Magnetic resonance imaging
  • Myocardial infarction
  • Remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Diffusion tensor magnetic resonance imaging mapping the fiber architecture remodeling in human myocardium after infarction : Correlation with viability and wall motion. / Wu, Ming Ting; Tseng, Wen Yih I; Su, Mao Yuan M; Liu, Chun Peng; Chiou, Kuan Rau; Wedeen, Van J.; Reese, Timothy G.; Yang, Chien Fang.

In: Circulation, Vol. 114, No. 10, 01.09.2006, p. 1036-1045.

Research output: Contribution to journalArticle

Wu, Ming Ting ; Tseng, Wen Yih I ; Su, Mao Yuan M ; Liu, Chun Peng ; Chiou, Kuan Rau ; Wedeen, Van J. ; Reese, Timothy G. ; Yang, Chien Fang. / Diffusion tensor magnetic resonance imaging mapping the fiber architecture remodeling in human myocardium after infarction : Correlation with viability and wall motion. In: Circulation. 2006 ; Vol. 114, No. 10. pp. 1036-1045.
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T1 - Diffusion tensor magnetic resonance imaging mapping the fiber architecture remodeling in human myocardium after infarction

T2 - Correlation with viability and wall motion

AU - Wu, Ming Ting

AU - Tseng, Wen Yih I

AU - Su, Mao Yuan M

AU - Liu, Chun Peng

AU - Chiou, Kuan Rau

AU - Wedeen, Van J.

AU - Reese, Timothy G.

AU - Yang, Chien Fang

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N2 - BACKGROUND - Diffusion tensor magnetic resonance imaging (DT-MRI) provides a means for nondestructive characterization of myocardial architecture. We used DT-MRI to investigate changes in direction-dependent water diffusivity to reflect alterations in tissue integrity (trace apparent diffusion coefficients [ADCs] and fractional anisotropy [FA]), as well as indicators of remodeling of fiber helix angles, in patients after myocardial infarction. METHODS AND RESULTS - Thirty-seven patients (35 men, 2 women; median age, 59) after acute myocardial infarction (median interval from onset, 26 days) were enrolled. DT-MRI was performed at the midventricular level to measure trace ADC, FA, and helix angles of myofibers. Helix angles were grouped into left-handed helical fibers, circumferential fibers, and right-handed helical fibers. Measurements were correlated with viability and regional wall motion assessed by contrast-delay-enhancement and cine MRI, respectively. The infarct zone showed significantly increased trace ADC and decreased FA than the remote zone. The percentage of left-handed helical fibers increased from the remote zone (mean±SD, 13.3±5.8%) to the adjacent zone (19.2±9.7%) and infarct zone (25.8±18.4%) (MANOVA, P=0.004). The percentage of right-handed helical fibers decreased from the remote zone (35.0±9.0%) to the adjacent zone (25.5±11.5%) and infarct zone (15.9±9.2%) (P<0.001). Multiple linear regression showed that the percentage of left-handed helical fibers of the infarct zone was the strongest correlate of infarct size and predictor of ejection fraction. CONCLUSIONS - In vivo DT-MRI of postinfarct myocardium revealed a significant increase in trace ADC and a decrease in FA, indicating altered tissue integrity. The redistribution of fiber architecture correlated with infarct size and left ventricular function. This technique may help us understand structural correlates of functional remodeling after infarction.

AB - BACKGROUND - Diffusion tensor magnetic resonance imaging (DT-MRI) provides a means for nondestructive characterization of myocardial architecture. We used DT-MRI to investigate changes in direction-dependent water diffusivity to reflect alterations in tissue integrity (trace apparent diffusion coefficients [ADCs] and fractional anisotropy [FA]), as well as indicators of remodeling of fiber helix angles, in patients after myocardial infarction. METHODS AND RESULTS - Thirty-seven patients (35 men, 2 women; median age, 59) after acute myocardial infarction (median interval from onset, 26 days) were enrolled. DT-MRI was performed at the midventricular level to measure trace ADC, FA, and helix angles of myofibers. Helix angles were grouped into left-handed helical fibers, circumferential fibers, and right-handed helical fibers. Measurements were correlated with viability and regional wall motion assessed by contrast-delay-enhancement and cine MRI, respectively. The infarct zone showed significantly increased trace ADC and decreased FA than the remote zone. The percentage of left-handed helical fibers increased from the remote zone (mean±SD, 13.3±5.8%) to the adjacent zone (19.2±9.7%) and infarct zone (25.8±18.4%) (MANOVA, P=0.004). The percentage of right-handed helical fibers decreased from the remote zone (35.0±9.0%) to the adjacent zone (25.5±11.5%) and infarct zone (15.9±9.2%) (P<0.001). Multiple linear regression showed that the percentage of left-handed helical fibers of the infarct zone was the strongest correlate of infarct size and predictor of ejection fraction. CONCLUSIONS - In vivo DT-MRI of postinfarct myocardium revealed a significant increase in trace ADC and a decrease in FA, indicating altered tissue integrity. The redistribution of fiber architecture correlated with infarct size and left ventricular function. This technique may help us understand structural correlates of functional remodeling after infarction.

KW - Magnetic resonance imaging

KW - Myocardial infarction

KW - Remodeling

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