Diffuse sclerosing variant of papillary thyroid carcinoma with multiple metastases and elevated serum carcinoembryonic antigen level

Chin Sung Kuo, Kam Tsun Tang, Jiun Dian Lin, An Hang Yang, Chen Hsen Lee, Hong Da Lin

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Background: Diffuse sclerosing variant of papillary thyroid carcinoma (DSPC) is a rare variant of papillary thyroid carcinoma (PTC). We report a 61-year-old female of DSPC whose course was complicated by multiple metastases and an elevated serum carcinoembryonic antigen (CEA) level. Summary: The patient presented with upper back pain. X-ray showed an osteolytic lesion of the sixth cervical spinous process. She had a hard, nonmovable mass with fixed enlarged lymph nodes (LNs) over right neck. Fine-needle aspiration cytology revealed PTC with LNs metastasis. Positron emission tomography demonstrated multiple brain, bone, liver, and lung metastases. However, the patient had an elevated serum CEA level. She underwent a total thyroidectomy and 200? mCi radioactive 131I therapy. The pathological findings were diffuse sclerosing variant of PTC with capsular and lymph vessel invasion. A double staining of tumor specimen appeared concomitantly positive for CEA and thyroglobulin. Conclusions: To our knowledge, DSPC with an elevated CEA level is extremely rare.

Original languageEnglish
Pages (from-to)1187-1190
Number of pages4
JournalThyroid
Volume22
Issue number11
DOIs
Publication statusPublished - Nov 1 2012

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Diffuse sclerosing variant of papillary thyroid carcinoma with multiple metastases and elevated serum carcinoembryonic antigen level'. Together they form a unique fingerprint.

Cite this