Differentiation of ketamine effects on renal nerve activity and renal blood flow in rats

Ya Jung Cheng, Chiang Ting Chien, Chien Yu Chen, Chau Fong Chen, Chen Jung Lin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: A biphasic pattern in the effects of increasing dose of ketamine on mean arterial blood pressure (MBP) and renal sympathetic nerve activities (RSNA) was shown in previous study. We hypothesized that if renal vascular resistance (RVR) and renal blood flow (RBF) are mainly controlled by RSNA, they will show a similar biphasic pattern under increasing doses of ketamine. Methods: 16 female Wistar rats anesthetized with urethane were studied for ketamine at 0.5, 1, 2 mg/kg, i.v. at 30 min intervals. Multifiber RSNA recording was studied in 8 rats and RBF (by electromagnetic flowmeter) and RVR were studied in the other 8 rats with intact renal nerves. Results: our results showed that although incremental doses of ketamine brought about a biphasic pattern in MBP and RSNA, the decrease in RBF and the increase in RVR went a dose-related way. Conclusions: We concluded that there was a differentiation of ketamine effects on renal nerve activity and renal blood flow in rats. The changes of RBF and RVR can not only be attributed to the effects of sympathetic nerve activities.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalActa Anaesthesiologica Taiwanica
Volume42
Issue number4
Publication statusPublished - Dec 1 2004
Externally publishedYes

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Keywords

  • Ketamine
  • Renal circulation
  • Sympathetic nervous system
  • Vascular resistance

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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