Differentiating disease subtypes by using pathway patterns constructed from gene expressions and protein networks

Fei Hung Hung, Hung Wen Chiu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Gene expression profiles differ in different diseases. Even if diseases are at the same stage, such diseases exhibit different gene expressions, not to mention the different subtypes at a single lesion site. Distinguishing different disease subtypes at a single lesion site is difficult. In early cases, subtypes were initially distinguished by doctors. Subsequently, further differences were found through pathological experiments. For example, a brain tumor can be classified according to its origin, its cell-type origin, or the tumor site. Because of the advancements in bioinformatics and the techniques for accumulating gene expressions, researchers can use gene expression data to classify disease subtypes. Because the operation of a biopathway is closely related to the disease mechanism, the application of gene expression profiles for clustering disease subtypes is insufficient. In this study, we collected gene expression data of healthy and four myelodysplastic syndrome subtypes and applied a method that integrated protein-protein interaction and gene expression data to identify different patterns of disease subtypes. We hope it is efficient for the classification of disease subtypes in adventure.

Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages6519-6522
Number of pages4
Volume2015-November
ISBN (Print)9781424492718
DOIs
Publication statusPublished - Nov 4 2015
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
Duration: Aug 25 2015Aug 29 2015

Other

Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
CountryItaly
CityMilan
Period8/25/158/29/15

Fingerprint

Gene expression
Proteins
Gene Expression
Transcriptome
Tumors
Myelodysplastic Syndromes
Computational Biology
Brain Neoplasms
Bioinformatics
Cluster Analysis
Brain
Research Personnel
Neoplasms

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Hung, F. H., & Chiu, H. W. (2015). Differentiating disease subtypes by using pathway patterns constructed from gene expressions and protein networks. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (Vol. 2015-November, pp. 6519-6522). [7319886] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7319886

Differentiating disease subtypes by using pathway patterns constructed from gene expressions and protein networks. / Hung, Fei Hung; Chiu, Hung Wen.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. p. 6519-6522 7319886.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hung, FH & Chiu, HW 2015, Differentiating disease subtypes by using pathway patterns constructed from gene expressions and protein networks. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. vol. 2015-November, 7319886, Institute of Electrical and Electronics Engineers Inc., pp. 6519-6522, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, 8/25/15. https://doi.org/10.1109/EMBC.2015.7319886
Hung FH, Chiu HW. Differentiating disease subtypes by using pathway patterns constructed from gene expressions and protein networks. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November. Institute of Electrical and Electronics Engineers Inc. 2015. p. 6519-6522. 7319886 https://doi.org/10.1109/EMBC.2015.7319886
Hung, Fei Hung ; Chiu, Hung Wen. / Differentiating disease subtypes by using pathway patterns constructed from gene expressions and protein networks. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. pp. 6519-6522
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