Differential whole-genome doubling and homologous recombination deficiencies across breast cancer subtypes from the Taiwanese population

Chia Hsin Wu, Chia Shan Hsieh, Yo Cheng Chang, Chi Cheng Huang, Hsien Tang Yeh, Ming Feng Hou, Yuan Chiang Chung, Shih Hsin Tu, King Jen Chang, Amrita Chattopadhyay, Liang Chuan Lai, Tzu Pin Lu, Yung Hua Li, Mong Hsun Tsai, Eric Y. Chuang

Research output: Contribution to journalArticlepeer-review

Abstract

Whole-genome doubling (WGD) is an early macro-evolutionary event in tumorigenesis, involving the doubling of an entire chromosome complement. However, its impact on breast cancer subtypes remains unclear. Here, we performed a comprehensive and quantitative analysis of WGD and its influence on breast cancer subtypes in patients from Taiwan and consequently highlight the genomic association between WGD and homologous recombination deficiency (HRD). A higher manifestation of WGD was reported in triple-negative breast cancer, conferring high chromosomal instability (CIN), while HER2 + tumors exhibited early WGD events, with widely varied CIN levels, compared to luminal-type tumors. An association of higher activity of de novo indel signature 2 with WGD and HRD in Taiwanese breast cancer patients was reported. A control test between WGD and pseudo non-WGD samples was further employed to support this finding. The study provides a better comprehension of tumorigenesis in breast cancer subtypes, thus assisting in personalized treatment.

Original languageEnglish
Article number1052
JournalCommunications Biology
Volume4
Issue number1
DOIs
Publication statusPublished - Dec 2021

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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