Differential tissue distribution of sesaminol triglucoside and its metabolites in rats fed with lignan glycosides from sesame meal with or without nano/submicrosizing

Chia Ding Liao, Wei Lun Hung, Wen Chien Lu, Kuo Ching Jan, Daniel Yang Chih Shih, A. N.I. Yeh, Chi Tang Ho, Lucy Sun Hwang

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Lignan glycosides are important functional compounds in sesame meal. In the present study, we Investigated whether the tissue distribution of nano/submicroslzed lignan glycosides from sesame meal (N-LGSM) differs from lignan glycosides from sesame meal (LGSM). LGSM was nano/ submicrosized with 0.3 mm zirconia beads as the milling media. The average particle size of the 4% LGSM aqueous suspension reduced rapidly from approximately 2 μm to 200 nm after media milling at an agitation speed of 3600 rpm for 30 min. We examined the tissue distribution of sesaminol triglucoside (ST), the main component in LGSM, in Sprague-Dawley (SD) rats. The concentrations of ST were determined in various tissues and plasma within a 24 h period after oral administration of N-LGSM and LGSM (800 mg/kg of body weight). The results showed that higher concentrations of ST and its metabolites (sesaminol, sesaminol sulfate, and sesaminol glucuronide) were found in N-LGSM compared to those in LGSM in most tissues, especially liver and small Intestine. Sesaminol glucuronide was the main metabolite In rats. After 3 h of oral administration, around 70% higher concentration of sesaminol glucuronide was found in N-LGSM compared to that in LGSM. This study clearly showed that LGSM Is more bioavailable after nano/submlcrosizing.

Original languageEnglish
Pages (from-to)563-569
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume58
Issue number1
DOIs
Publication statusPublished - Jan 13 2010
Externally publishedYes

Keywords

  • Metabolites
  • Nanosuspenslon
  • Sesame meal
  • Sesamlnol trlglucoslde
  • Tissue distribution

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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