Differential roles of basolateral and central amygdala on the effects of uncontrollable stress on hippocampal synaptic plasticity

Chih Hao Yang, Chiung Chun Huang, Kuei Sen Hsu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The amygdala is considered central in mediating stress-related changes of hippocampal functions. However, it remains unclear whether different amygdala subnuclei have different roles in coordinating stress effects. Here, we report that stress exposure caused an immediate increase of extracellular signal-regulated kinase (ERK)1/2 phosphorylation in the hippocampal area CA1 and the basolateral amygdala (BLA) and after a delay in the central amygdala (CEA). Exposure to the novel environment following stress increased ERK1/2 phosphorylation in the CEA, but reversed the stress-induced increase of ERK1/2 phosphorylation in the hippocampal area CA1 and the BLA. Either ERK1/2 inhibitor U0126 or N-methyl-D-aspartate (NMDA) receptor antagonist DL-(-)-2-amino-5- phosphonopentanoic acid (APV) administration into the BLA, but not the CEA, blocked the stress effects on hippocampal long-term potentiation (LTP) and long-term depression. Novelty-exploration-induced reversal of stress effects was prevented when animals were injected U0126 or APV into the CEA, but not the BLA, before subjected to the novel environment. The ability of novelty exploration to reverse the stress effects was mimicked by intra-CEA infusion of NMDA. These findings suggest that BLA ERK1/2 signaling pathway is critical to mediate the stress effects on hippocampal synaptic plasticity; the activation of CEA ERK1/2, in contrast, appears to mediate the reversal of Stress effects.

Original languageEnglish
Pages (from-to)548-563
Number of pages16
JournalHippocampus
Volume18
Issue number6
DOIs
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Neuronal Plasticity
Phosphorylation
Amygdala
2-Amino-5-phosphonovalerate
Mitogen-Activated Protein Kinase 3
MAP Kinase Signaling System
Long-Term Potentiation
Mitogen-Activated Protein Kinase 1
N-Methylaspartate
N-Methyl-D-Aspartate Receptors
Basolateral Nuclear Complex
Central Amygdaloid Nucleus

Keywords

  • Amygadala
  • Hippocampus
  • Long-term depression
  • Long-term potentiation
  • Stress

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Differential roles of basolateral and central amygdala on the effects of uncontrollable stress on hippocampal synaptic plasticity. / Yang, Chih Hao; Huang, Chiung Chun; Hsu, Kuei Sen.

In: Hippocampus, Vol. 18, No. 6, 2008, p. 548-563.

Research output: Contribution to journalArticle

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