Differential Impact of IL-10 Expression on Survival and Relapse between HPV16-Positive and -Negative Oral Squamous Cell Carcinomas

Chun Yi Chuang, Wen Wei Sung, Lee Wang, Wea Long Lin, Kun Tu Yeh, Mao Chang Su, Chun Han Hsin, Shiann Yann Lee, Buor Chang Wu, Ya Wen Cheng, Huei Lee

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Human papillomavirus (HPV) is a risk factor in a subset of oropharyngeal cancer; however, the contribution of HPV in the malignancy of oral squamous cell carcinomas (OSCC) is not fully understood in Taiwanese. Herein, 61 patients with no risk factors and 117 patients with one or more risk factors were enrolled in this study. HPV16/18 infection rate in non-smokers, non-drinkers and non-betel quid chewers was higher than their counterparts. The development of HPV-infected cancer has been shown to be associated with interleukin-10 (IL-10) expression. To this end, IL-10 mRNA expression in OSCC tumors was evaluated by real-time RT-PCR. Data showed that HPV-positive patients had higher IL-10 mRNA levels than in HPV-negative patients. Kaplan-Meier and Cox-regression analysis indicated that the prognostic significance of IL-10 mRNA on overall survival and relapse free survival was only observed in HPV-positive OSCC, but not in HPV-negative OSCC. Mechanistically, the elevation of IL-10 by E6 was responsible for increased colony formation and migration capability in OSCC cells. Therefore, we suggest that IL-10 induced by E6 promotes cell growth and migration capability and consequent poor survival and relapse in HPV-positive OSCC.

Original languageEnglish
Article numbere47541
JournalPLoS One
Volume7
Issue number10
DOIs
Publication statusPublished - Oct 31 2012

Fingerprint

Papillomaviridae
relapse
squamous cell carcinoma
interleukin-10
Interleukin-10
Squamous Cell Carcinoma
mouth
Recurrence
Survival
Messenger RNA
risk factors
Oropharyngeal Neoplasms
Cell growth
Neoplasms
Set theory
Regression analysis
Human Development
neoplasms
human development
Epithelial Cells

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Differential Impact of IL-10 Expression on Survival and Relapse between HPV16-Positive and -Negative Oral Squamous Cell Carcinomas. / Chuang, Chun Yi; Sung, Wen Wei; Wang, Lee; Lin, Wea Long; Yeh, Kun Tu; Su, Mao Chang; Hsin, Chun Han; Lee, Shiann Yann; Wu, Buor Chang; Cheng, Ya Wen; Lee, Huei.

In: PLoS One, Vol. 7, No. 10, e47541, 31.10.2012.

Research output: Contribution to journalArticle

Chuang, CY, Sung, WW, Wang, L, Lin, WL, Yeh, KT, Su, MC, Hsin, CH, Lee, SY, Wu, BC, Cheng, YW & Lee, H 2012, 'Differential Impact of IL-10 Expression on Survival and Relapse between HPV16-Positive and -Negative Oral Squamous Cell Carcinomas', PLoS One, vol. 7, no. 10, e47541. https://doi.org/10.1371/journal.pone.0047541
Chuang, Chun Yi ; Sung, Wen Wei ; Wang, Lee ; Lin, Wea Long ; Yeh, Kun Tu ; Su, Mao Chang ; Hsin, Chun Han ; Lee, Shiann Yann ; Wu, Buor Chang ; Cheng, Ya Wen ; Lee, Huei. / Differential Impact of IL-10 Expression on Survival and Relapse between HPV16-Positive and -Negative Oral Squamous Cell Carcinomas. In: PLoS One. 2012 ; Vol. 7, No. 10.
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