Differential effects of olanzapine and clozapine on plasma levels of adipocytokines and total ghrelin

Mong Liang Lu, Tsu Nai Wang, Tsang Yaw Lin, Wen Chuan Shao, Sheng Huang Chang, Jen Yu Chou, Yi Feng Ho, Yin To Liao, Vincent Chin Hung Chen

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Second-generation antipsychotics (SGAs) have been associated with an increased liability for weight gain and metabolic side effects. Among SGAs, clozapine and olanzapine had great liability to induce weight gain and metabolic adverse reactions. Leptin, adiponectin, and total ghrelin play important roles in energy homeostasis and are suggested to be biomarkers of metabolic disturbances. The purpose of the present study was to investigate the differential effects of antipsychotics (olanzapine and clozapine) on the levels of adipocytokines (leptin and adiponectin) and total ghrelin.Three hundred and thirty-three patients with schizophrenia under clozapine or olanzapine monotherapy were recruited. Control participants were recruited from a healthy community population based on a health investigation (N= 119). Fasting blood samples for glucose, cholesterol, triglycerides, leptin, adiponectin, and total ghrelin were analyzed.There were significant differences in the levels of cholesterol, triglycerides, and glucose between these three groups. Post hoc comparisons showed that the olanzapine group had the highest levels of cholesterol and triglycerides. The levels of leptin, adiponectin, and total ghrelin were also significantly different between the three groups after controlling age and body mass index (BMI). Post hoc comparisons showed that the olanzapine group had the lowest levels of adiponectin and total ghrelin.The present study found that the uses of olanzapine and clozapine were associated with changes in adipocytokines and total ghrelin, even after adjusting potential confounding factors. Olanzapine had greater influences on adiponectin and total ghrelin than clozapine. The changes in adipocytokines and total ghrelin were a direct effect of antipsychotics on hormonal pathways of energy homeostasis, rather than the result of weight gain.

Original languageEnglish
Pages (from-to)47-50
Number of pages4
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume58
DOIs
Publication statusPublished - Apr 3 2015

Fingerprint

olanzapine
Ghrelin
Adipokines
Clozapine
Adiponectin
Leptin
Antipsychotic Agents
Weight Gain
Triglycerides
Homeostasis
Cholesterol
Hypercholesterolemia
Blood Glucose
Fasting
Schizophrenia

Keywords

  • Adiponectin
  • Clozapine
  • Ghrelin
  • Leptin
  • Olanzapine
  • Schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Differential effects of olanzapine and clozapine on plasma levels of adipocytokines and total ghrelin. / Lu, Mong Liang; Wang, Tsu Nai; Lin, Tsang Yaw; Shao, Wen Chuan; Chang, Sheng Huang; Chou, Jen Yu; Ho, Yi Feng; Liao, Yin To; Chen, Vincent Chin Hung.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 58, 03.04.2015, p. 47-50.

Research output: Contribution to journalArticle

Lu, Mong Liang ; Wang, Tsu Nai ; Lin, Tsang Yaw ; Shao, Wen Chuan ; Chang, Sheng Huang ; Chou, Jen Yu ; Ho, Yi Feng ; Liao, Yin To ; Chen, Vincent Chin Hung. / Differential effects of olanzapine and clozapine on plasma levels of adipocytokines and total ghrelin. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2015 ; Vol. 58. pp. 47-50.
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AU - Lu, Mong Liang

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AU - Lin, Tsang Yaw

AU - Shao, Wen Chuan

AU - Chang, Sheng Huang

AU - Chou, Jen Yu

AU - Ho, Yi Feng

AU - Liao, Yin To

AU - Chen, Vincent Chin Hung

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