Differential effect of high dietary fat intakes on haemorheological parameters in rats

Cheng Jeng Tai; Chao Hsiang Chen; Hui Hsin Chen; Hong Jen Liang

doi:10.1017/S0007114509992704

Differential effect of high dietary fat intakes on haemorheological parameters in rats

Cheng Jeng Tai, Chao Hsiang Chen, Hui Hsin Chen, Hong Jen Liang

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

High dietary intake of fats has been thought to be one of the major risk factors for the development of CVD. Less is known about the possible influence of fats from various sources on haemorheological abnormalities, which are considered an important factor in the pathogenesis of these diseases. The goal of the present study was to investigate effects of high-fat diets enriched in unsaturated fatty acids (USFA), SFA or trans-fatty acids (TFA), respectively, on haemorheological parameters in rats. Wistar female rats were divided into four groups and fed diets based on the AIN-93M formulation containing approximately 10% energy from soyabean oil (control group) or 40% energy from soyabean oil (USFA), palm oil (SFA) and vegetable shortening (TFA) for 8 weeks. The results showed that rats fed high-fat diets exhibited significant increases in serum TAG levels (P

Original language	English
Pages (from-to)	977-983
Number of pages	7
Journal	British Journal of Nutrition
Volume	103
Issue number	7
DOIs	https://doi.org/10.1017/S0007114509992704
Publication status	Published - Apr 2010

Keywords

Blood viscosity
Erythrocyte aggregation
Erythrocyte deformability
Free radicals
High fat intake
Plasma viscosity
SFA
Trans-fatty acids
Unsaturated fatty acids

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics
Medicine(all)

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abstract = "High dietary intake of fats has been thought to be one of the major risk factors for the development of CVD. Less is known about the possible influence of fats from various sources on haemorheological abnormalities, which are considered an important factor in the pathogenesis of these diseases. The goal of the present study was to investigate effects of high-fat diets enriched in unsaturated fatty acids (USFA), SFA or trans-fatty acids (TFA), respectively, on haemorheological parameters in rats. Wistar female rats were divided into four groups and fed diets based on the AIN-93M formulation containing approximately 10% energy from soyabean oil (control group) or 40% energy from soyabean oil (USFA), palm oil (SFA) and vegetable shortening (TFA) for 8 weeks. The results showed that rats fed high-fat diets exhibited significant increases in serum TAG levels (P",

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AU - Chen, Hui Hsin

AU - Liang, Hong Jen

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