Differential alterations of resting-state functional connectivity in generalized anxiety disorder and panic disorder

Huiru Cui, Jie Zhang, Yicen Liu, Qingwei Li, Hui Li, Lanlan Zhang, Qiang Hu, Wei Cheng, Qiang Luo, Jianqi Li, Wei Li, Jijun Wang, Jianfeng Feng, Chunbo Li, Georg Northoff

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Generalized anxiety disorder (GAD) and panic disorder (PD) are most common anxiety disorders with high lifetime prevalence while the pathophysiology and disease-specific alterations still remain largely unclear. Few studies have taken a whole-brain perspective in the functional connectivity (FC) analysis of these two disorders in resting state. It limits the ability to identify regionally and psychopathologically specific network abnormalities with their subsequent use as diagnostic marker and novel treatment strategy. The whole brain FC using a novel FC metric was compared, that is, scaled correlation, which they demonstrated to be a reliable FC statistics, but have higher statistical power in two-sample t-test of whole brain FC analysis. About 21 GAD and 18 PD patients were compared with 22 matched control subjects during resting-state, respectively. It was found that GAD patients demonstrated increased FC between hippocampus/parahippocampus and fusiform gyrus among the most significantly changed FC, while PD was mainly associated with greater FC between somatosensory cortex and thalamus. Besides such regional specificity, it was observed that psychopathological specificity in that the disrupted FC pattern in PD and GAD correlated with their respective symptom severity. The findings suggested that the increased FC between hippocampus/parahippocampus and fusiform gyrus in GAD were mainly associated with a fear generalization related neural circuit, while the greater FC between somatosensory cortex and thalamus in PD were more likely linked to interoceptive processing. Due to the observed regional and psychopathological specificity, their findings bear important clinical implications for the potential treatment strategy.

Original languageEnglish
Pages (from-to)1459-1473
Number of pages15
JournalHuman Brain Mapping
Volume37
Issue number4
DOIs
Publication statusPublished - Apr 1 2016

Fingerprint

Panic Disorder
Anxiety Disorders
Somatosensory Cortex
Temporal Lobe
Thalamus
Hippocampus
Brain
Aptitude
Fear
Therapeutics

Keywords

  • Anxiety disorders
  • Fear
  • Functional magnetic resonance imaging (fMRI)
  • Generalization
  • Interoception; whole brain functional connectivity analysis

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Differential alterations of resting-state functional connectivity in generalized anxiety disorder and panic disorder. / Cui, Huiru; Zhang, Jie; Liu, Yicen; Li, Qingwei; Li, Hui; Zhang, Lanlan; Hu, Qiang; Cheng, Wei; Luo, Qiang; Li, Jianqi; Li, Wei; Wang, Jijun; Feng, Jianfeng; Li, Chunbo; Northoff, Georg.

In: Human Brain Mapping, Vol. 37, No. 4, 01.04.2016, p. 1459-1473.

Research output: Contribution to journalArticle

Cui, H, Zhang, J, Liu, Y, Li, Q, Li, H, Zhang, L, Hu, Q, Cheng, W, Luo, Q, Li, J, Li, W, Wang, J, Feng, J, Li, C & Northoff, G 2016, 'Differential alterations of resting-state functional connectivity in generalized anxiety disorder and panic disorder', Human Brain Mapping, vol. 37, no. 4, pp. 1459-1473. https://doi.org/10.1002/hbm.23113
Cui, Huiru ; Zhang, Jie ; Liu, Yicen ; Li, Qingwei ; Li, Hui ; Zhang, Lanlan ; Hu, Qiang ; Cheng, Wei ; Luo, Qiang ; Li, Jianqi ; Li, Wei ; Wang, Jijun ; Feng, Jianfeng ; Li, Chunbo ; Northoff, Georg. / Differential alterations of resting-state functional connectivity in generalized anxiety disorder and panic disorder. In: Human Brain Mapping. 2016 ; Vol. 37, No. 4. pp. 1459-1473.
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