Different Mechanisms of Airway Hyperresponsiveness between Exercise and Methacholine-Induced Bronchoconstriction in Chronic Asthma

林 孟賢(Meng-Hsien Lin), 蘇 榮璋(Jung-Chang Su), 鄭 志賢(Chi-Hsien Cheng), 林 鴻銓(Horng-Chyuan Lin), 王 圳華(Chun-Hua Wang), 江 玲玲(Ling-Ling Chiang), 郭 漢彬(Han-Pin Kuo)

Research output: Contribution to journalArticle

Abstract

Purpose: The aim of this study was to explore the different mechanisms of exercise-(EIB) and methacholine-(MIB) induced bronchoconstriction in patients with chronic asthma. Methods: We measured the FEV1, recovery time (RT), and AUC 0-60 min (area under the curve from 0 to 60 min after exercise in FEV1) in 41 asthmatics, who received exercise and methacholine challenge tests. Results: Among these asthmatics, 12 asthmatics had EIB and 29 had no EIB. The recovery time was prolonged (109.2 ±26.5 min, n= 11, p<0.001) and AUC 0-60 min was larger (1201.0 ± 70.0 % ‧min, p<0.0001) in the EIB group, compared to the non-EIB group (RT : 36.9±5.9 min; AUC : 328.0 ± 28.0 %·min, respectively, n=28). There was no difference in AUC and RT after methacholine-induced bronchoconstriction between the EIB and non-EIB groups (1136.0 ± 115.8 versus 1121.0 ± 122.7 %.min, p= 0.936; 111.5 ± 14.2 versus 106.0 ± 14.3 min, p=0.757 ). There was no significant correlation between the magnitude of AUC induced by exercise test or methacholine challenge (r= 0.24) Conclusion: We suggested that there were different mechanisms between EIB and MIB. The delayed bronchodilation in the EIB asthmatic subjects was probably related to presence of bronchoconstrictors.
Translated title of the contribution慢性氣喘病人在運動(exercise)誘發性或醯丑甲基膽鹼 (methacholine) 誘發性氣道收縮下,有不同的氣道過度反應機制
Original languageEnglish
Pages (from-to)116-123
Number of pages8
Journal胸腔醫學
Volume18
Issue number2
Publication statusPublished - 2003

Keywords

  • exercise-induced bronchoconstriction
  • methacholine-induced bronchoconstriction
  • asthma
  • recovery time
  • area under curve

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    林孟賢(Meng-Hsien L, 蘇榮璋(Jung-Chang S, 鄭志賢(Chi-Hsien C, 林鴻銓(Horng-Chyuan L, 王圳華(Chun-Hua W, 江玲玲(Ling-Ling C, & 郭漢彬(Han-Pin K (2003). Different Mechanisms of Airway Hyperresponsiveness between Exercise and Methacholine-Induced Bronchoconstriction in Chronic Asthma. 胸腔醫學, 18(2), 116-123. http://www.AiritiLibrary.com/Publication/Index/10239855-200304-18-2-116-123-a