Different impact of IL10 haplotype on prognosis in lung squamous cell carcinoma and adenocarcinoma

Yaw Cheng Wang, Wen Wei Sung, Lee Wang, Ya Wen Cheng, Chih Yi Chen, Tzu Chin Wu, Shwn Huey Shieh, Huei Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Polymorphisms (1082A>G, - 819C>T, and -592G>A) in the interleukin-10 (IL10) promoter are associated with its transcriptional activity. IL10 induction by cigarette smoking plays a role in smokingrelated lung tumor progression. We therefore expected to find a difference in impact of IL10 haplotypes on overall survival (OS) and relapse-free survival (RFS) between squamous cell carcinomas (SCC) and adenocarcinomas (ADC) of lung. Materials and Methods: Normal lung tissues adjacent to resected tumors from 439 lung cancer patients were collected to determine IL10 haplotypes (ATA and non-ATA) by direct sequencing and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Kaplan-Meier and multivariate Cox regression models were used to assess the impact of IL10 haplotype on OS and RFS. Resluts: The non-ATA haplotype was more prevalent in patients with nodal metastatic tumors (N1 and N2) than in those with nonnodal metastatic tumors (N0). This observation was only made for patients with SCC and not ADC. Patients with SCC with the non-ATA haplotype had poorer OS and RFS when compared to those with the ATA haplotype, whereas IL10 haplotype was not associated with the clinical outcome of patients with ADC. Conclusion: The IL10 haplotype may independently predict survival and relapse in patients with surgically resected SCC, but not ADC.

Original languageEnglish
Pages (from-to)2729-2736
Number of pages8
JournalAnticancer Research
Volume33
Issue number6
Publication statusPublished - Jun 2013

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Interleukin-10
Haplotypes
Squamous Cell Carcinoma
Adenocarcinoma
Lung
Survival
Recurrence
Neoplasms
Proportional Hazards Models
Restriction Fragment Length Polymorphisms
Lung Neoplasms
Smoking
Polymerase Chain Reaction

Keywords

  • Adenocarcinoma
  • Haplotype
  • IL10
  • Lung cancer
  • Prognosis
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Wang, Y. C., Sung, W. W., Wang, L., Cheng, Y. W., Chen, C. Y., Wu, T. C., ... Lee, H. (2013). Different impact of IL10 haplotype on prognosis in lung squamous cell carcinoma and adenocarcinoma. Anticancer Research, 33(6), 2729-2736.

Different impact of IL10 haplotype on prognosis in lung squamous cell carcinoma and adenocarcinoma. / Wang, Yaw Cheng; Sung, Wen Wei; Wang, Lee; Cheng, Ya Wen; Chen, Chih Yi; Wu, Tzu Chin; Shieh, Shwn Huey; Lee, Huei.

In: Anticancer Research, Vol. 33, No. 6, 06.2013, p. 2729-2736.

Research output: Contribution to journalArticle

Wang, YC, Sung, WW, Wang, L, Cheng, YW, Chen, CY, Wu, TC, Shieh, SH & Lee, H 2013, 'Different impact of IL10 haplotype on prognosis in lung squamous cell carcinoma and adenocarcinoma', Anticancer Research, vol. 33, no. 6, pp. 2729-2736.
Wang YC, Sung WW, Wang L, Cheng YW, Chen CY, Wu TC et al. Different impact of IL10 haplotype on prognosis in lung squamous cell carcinoma and adenocarcinoma. Anticancer Research. 2013 Jun;33(6):2729-2736.
Wang, Yaw Cheng ; Sung, Wen Wei ; Wang, Lee ; Cheng, Ya Wen ; Chen, Chih Yi ; Wu, Tzu Chin ; Shieh, Shwn Huey ; Lee, Huei. / Different impact of IL10 haplotype on prognosis in lung squamous cell carcinoma and adenocarcinoma. In: Anticancer Research. 2013 ; Vol. 33, No. 6. pp. 2729-2736.
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AU - Shieh, Shwn Huey

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