Different effects of dronedarone and amiodarone on pulmonary vein electrophysiology, mechanical properties and H2O2-induced arrhythmogenicity

Dicky Armein Hanafy, Yao Chang Chen, Shih Lin Chang, Yen Yu Lu, Yung-Kuo Lin, Yu-Hsun Kao, Shih A. Chen, Yi-Jen Chen

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5 Citations (Scopus)


Dronedarone and amiodarone are anti-atrial fibrillation agents with different potency. Pulmonary veins play a critical role in the genesis of atrial fibrillation. Oxidative stress can enhance pulmonary vein arrhythmogenesis. This study was done to compare the effects of dronedarone and amiodarone on pulmonary vein electrophysiological and mechanical properties, and oxidative stress-induced arrhythmogenecity. Conventional microelectrodes were used to record action potentials in isolated rabbit pulmonary vein specimens before and after dronedarone and amiodarone with or without the presence of H 2O2 (2 mM). Dronedarone (0.1, 1 and 10 μM) concentration-dependently decreased pulmonary vein beating rates (from 2.2±0.1 to 1.9±0.1, 1.8±0.1 and 1.7±0.1 Hz, n=8, P2O2-induced pulmonary vein burst firings from 100% to 33.3% (P2O2-induced pulmonary vein arrhythmogenesis. However, only dronedarone produced pulmonary vein vasodilation.

Original languageEnglish
Pages (from-to)103-108
Number of pages6
JournalEuropean Journal of Pharmacology
Issue number1-3
Publication statusPublished - Feb 28 2013



  • Amiodarone
  • Atrial fibrillation
  • Dronedarone
  • Oxidative stress
  • Pulmonary vein

ASJC Scopus subject areas

  • Pharmacology

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