Abstract

Objectives The aim of the study is to investigate the efficacy of different dosages of single bolus propofol administered on the basis of total body weight or corrected body weight for the intravenous induction of anesthesia in obese patients undergoing bariatric surgery. Materials and methods Thirty-eight obese patients with a body mass index (BMI) of 30 kg/m2 or greater were randomly divided into two groups. They received single-bolus propofol (2 mg/kg) for intravenous induction of anesthesia based on either total body weight (TBW; 20 patients) or corrected body weight 60% (CBW60; 18 patients). Patients' characteristics, biochemical data, monitored bispectral index (BIS) values, and hemodynamic parameters were compared between the two groups. Results The propofol dose was significantly lower in the CBW60 group than in the TBW group (189.5 ± 36.3 mg vs. 217.3 ± 39.1 mg, respectively; p = 0.03). The highest BIS value, representing potential awareness after intubation, was relatively higher in the CBW60 group, but this difference was not statistically significant (CBW60 group, 53.6 ± 11.1; TBW group, 48.6 ± 8.1; p = 0.22). Eighty-three percent of patients experienced hypotension during induction and at least 44% patients showed marked hypotension. There was no significant difference between the TBW and CBW60 groups in blood pressure after intubation. Conclusion When using single bolus propofol, the CBW60 group showed similar BIS values and hemodynamic effects as the TBW group during the intravenous induction of general anesthesia for obese patients.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalActa Anaesthesiologica Taiwanica
Volume51
Issue number2
DOIs
Publication statusPublished - Jun 2013

Fingerprint

Propofol
Body Weight
Intravenous Anesthesia
Intubation
Hypotension
Hemodynamics
Bariatric Surgery
General Anesthesia
Body Mass Index
Blood Pressure

Keywords

  • electroencephalography bispectral index obesity propofol

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Different dosing regimens for propofol induction in obese patients. / Lam, Fai; Liao, Chien-Chang; Lee, Yi Jui; Wang, Weu; Kuo, Chien Ju; Lin, Chao-Shun.

In: Acta Anaesthesiologica Taiwanica, Vol. 51, No. 2, 06.2013, p. 53-57.

Research output: Contribution to journalArticle

@article{6037f16f66944d69bb26b695d8a5e385,
title = "Different dosing regimens for propofol induction in obese patients",
abstract = "Objectives The aim of the study is to investigate the efficacy of different dosages of single bolus propofol administered on the basis of total body weight or corrected body weight for the intravenous induction of anesthesia in obese patients undergoing bariatric surgery. Materials and methods Thirty-eight obese patients with a body mass index (BMI) of 30 kg/m2 or greater were randomly divided into two groups. They received single-bolus propofol (2 mg/kg) for intravenous induction of anesthesia based on either total body weight (TBW; 20 patients) or corrected body weight 60{\%} (CBW60; 18 patients). Patients' characteristics, biochemical data, monitored bispectral index (BIS) values, and hemodynamic parameters were compared between the two groups. Results The propofol dose was significantly lower in the CBW60 group than in the TBW group (189.5 ± 36.3 mg vs. 217.3 ± 39.1 mg, respectively; p = 0.03). The highest BIS value, representing potential awareness after intubation, was relatively higher in the CBW60 group, but this difference was not statistically significant (CBW60 group, 53.6 ± 11.1; TBW group, 48.6 ± 8.1; p = 0.22). Eighty-three percent of patients experienced hypotension during induction and at least 44{\%} patients showed marked hypotension. There was no significant difference between the TBW and CBW60 groups in blood pressure after intubation. Conclusion When using single bolus propofol, the CBW60 group showed similar BIS values and hemodynamic effects as the TBW group during the intravenous induction of general anesthesia for obese patients.",
keywords = "electroencephalography bispectral index obesity propofol",
author = "Fai Lam and Chien-Chang Liao and Lee, {Yi Jui} and Weu Wang and Kuo, {Chien Ju} and Chao-Shun Lin",
year = "2013",
month = "6",
doi = "10.1016/j.aat.2013.06.009",
language = "English",
volume = "51",
pages = "53--57",
journal = "Asian Journal of Anesthesiology",
issn = "2468-824X",
publisher = "Elsevier Taiwan LLC",
number = "2",

}

TY - JOUR

T1 - Different dosing regimens for propofol induction in obese patients

AU - Lam, Fai

AU - Liao, Chien-Chang

AU - Lee, Yi Jui

AU - Wang, Weu

AU - Kuo, Chien Ju

AU - Lin, Chao-Shun

PY - 2013/6

Y1 - 2013/6

N2 - Objectives The aim of the study is to investigate the efficacy of different dosages of single bolus propofol administered on the basis of total body weight or corrected body weight for the intravenous induction of anesthesia in obese patients undergoing bariatric surgery. Materials and methods Thirty-eight obese patients with a body mass index (BMI) of 30 kg/m2 or greater were randomly divided into two groups. They received single-bolus propofol (2 mg/kg) for intravenous induction of anesthesia based on either total body weight (TBW; 20 patients) or corrected body weight 60% (CBW60; 18 patients). Patients' characteristics, biochemical data, monitored bispectral index (BIS) values, and hemodynamic parameters were compared between the two groups. Results The propofol dose was significantly lower in the CBW60 group than in the TBW group (189.5 ± 36.3 mg vs. 217.3 ± 39.1 mg, respectively; p = 0.03). The highest BIS value, representing potential awareness after intubation, was relatively higher in the CBW60 group, but this difference was not statistically significant (CBW60 group, 53.6 ± 11.1; TBW group, 48.6 ± 8.1; p = 0.22). Eighty-three percent of patients experienced hypotension during induction and at least 44% patients showed marked hypotension. There was no significant difference between the TBW and CBW60 groups in blood pressure after intubation. Conclusion When using single bolus propofol, the CBW60 group showed similar BIS values and hemodynamic effects as the TBW group during the intravenous induction of general anesthesia for obese patients.

AB - Objectives The aim of the study is to investigate the efficacy of different dosages of single bolus propofol administered on the basis of total body weight or corrected body weight for the intravenous induction of anesthesia in obese patients undergoing bariatric surgery. Materials and methods Thirty-eight obese patients with a body mass index (BMI) of 30 kg/m2 or greater were randomly divided into two groups. They received single-bolus propofol (2 mg/kg) for intravenous induction of anesthesia based on either total body weight (TBW; 20 patients) or corrected body weight 60% (CBW60; 18 patients). Patients' characteristics, biochemical data, monitored bispectral index (BIS) values, and hemodynamic parameters were compared between the two groups. Results The propofol dose was significantly lower in the CBW60 group than in the TBW group (189.5 ± 36.3 mg vs. 217.3 ± 39.1 mg, respectively; p = 0.03). The highest BIS value, representing potential awareness after intubation, was relatively higher in the CBW60 group, but this difference was not statistically significant (CBW60 group, 53.6 ± 11.1; TBW group, 48.6 ± 8.1; p = 0.22). Eighty-three percent of patients experienced hypotension during induction and at least 44% patients showed marked hypotension. There was no significant difference between the TBW and CBW60 groups in blood pressure after intubation. Conclusion When using single bolus propofol, the CBW60 group showed similar BIS values and hemodynamic effects as the TBW group during the intravenous induction of general anesthesia for obese patients.

KW - electroencephalography bispectral index obesity propofol

UR - http://www.scopus.com/inward/record.url?scp=84882819943&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882819943&partnerID=8YFLogxK

U2 - 10.1016/j.aat.2013.06.009

DO - 10.1016/j.aat.2013.06.009

M3 - Article

C2 - 23968654

AN - SCOPUS:84882819943

VL - 51

SP - 53

EP - 57

JO - Asian Journal of Anesthesiology

JF - Asian Journal of Anesthesiology

SN - 2468-824X

IS - 2

ER -