Differences in the mode of exudative reaction between early phase and late phase of carrageenin-induced inflammation in rats

Wen Chang Chang, Susumu Tsurufuji

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Differences in the mode of vascular permeability change induced by some stimulants such as chemical mediators between the early phase and the late phase of the carrageenin-induced granulomatous inflammation were investigated with the aid of 131I-human serum albumin as an indicator for the measurement of vascular permeability. In the early pregranulomatous phase of the inflammation, histamine injection into the inflammation locus markedly elevated local vascular permeability, while prostaglandins E1 and E2 showed no effect. On the other hand, in the late phase of the inflammation, where permanent granuloma tissue had been formed, prostaglandins E1 and E2 significantly enhanced the local vascular permeability, while histamine was inert.

Original languageEnglish
Pages (from-to)7-14
Number of pages8
JournalEuropean Journal of Pharmacology
Volume36
Issue number1
DOIs
Publication statusPublished - 1976
Externally publishedYes

Fingerprint

Carrageenan
Capillary Permeability
Inflammation
Alprostadil
Dinoprostone
Histamine
Granuloma
Serum Albumin
Injections

Keywords

  • I-HSA
  • Carrageenin granuloma
  • Histamine
  • Prostaglandin Exudative reaction
  • Vascular permeability

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

@article{d94fca359c5640a3af8d04ecf9b5c6b3,
title = "Differences in the mode of exudative reaction between early phase and late phase of carrageenin-induced inflammation in rats",
abstract = "Differences in the mode of vascular permeability change induced by some stimulants such as chemical mediators between the early phase and the late phase of the carrageenin-induced granulomatous inflammation were investigated with the aid of 131I-human serum albumin as an indicator for the measurement of vascular permeability. In the early pregranulomatous phase of the inflammation, histamine injection into the inflammation locus markedly elevated local vascular permeability, while prostaglandins E1 and E2 showed no effect. On the other hand, in the late phase of the inflammation, where permanent granuloma tissue had been formed, prostaglandins E1 and E2 significantly enhanced the local vascular permeability, while histamine was inert.",
keywords = "I-HSA, Carrageenin granuloma, Histamine, Prostaglandin Exudative reaction, Vascular permeability",
author = "Chang, {Wen Chang} and Susumu Tsurufuji",
year = "1976",
doi = "10.1016/0014-2999(76)90250-8",
language = "English",
volume = "36",
pages = "7--14",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Differences in the mode of exudative reaction between early phase and late phase of carrageenin-induced inflammation in rats

AU - Chang, Wen Chang

AU - Tsurufuji, Susumu

PY - 1976

Y1 - 1976

N2 - Differences in the mode of vascular permeability change induced by some stimulants such as chemical mediators between the early phase and the late phase of the carrageenin-induced granulomatous inflammation were investigated with the aid of 131I-human serum albumin as an indicator for the measurement of vascular permeability. In the early pregranulomatous phase of the inflammation, histamine injection into the inflammation locus markedly elevated local vascular permeability, while prostaglandins E1 and E2 showed no effect. On the other hand, in the late phase of the inflammation, where permanent granuloma tissue had been formed, prostaglandins E1 and E2 significantly enhanced the local vascular permeability, while histamine was inert.

AB - Differences in the mode of vascular permeability change induced by some stimulants such as chemical mediators between the early phase and the late phase of the carrageenin-induced granulomatous inflammation were investigated with the aid of 131I-human serum albumin as an indicator for the measurement of vascular permeability. In the early pregranulomatous phase of the inflammation, histamine injection into the inflammation locus markedly elevated local vascular permeability, while prostaglandins E1 and E2 showed no effect. On the other hand, in the late phase of the inflammation, where permanent granuloma tissue had been formed, prostaglandins E1 and E2 significantly enhanced the local vascular permeability, while histamine was inert.

KW - I-HSA

KW - Carrageenin granuloma

KW - Histamine

KW - Prostaglandin Exudative reaction

KW - Vascular permeability

UR - http://www.scopus.com/inward/record.url?scp=0017104635&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017104635&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(76)90250-8

DO - 10.1016/0014-2999(76)90250-8

M3 - Article

C2 - 1261607

AN - SCOPUS:0017104635

VL - 36

SP - 7

EP - 14

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1

ER -