Differences between white and Chinese populations in human leukocyte antigen sharing and gestational trophoblastic tumors

Hong Nerng Ho, Thomas J. Gill, Bernard Klionsky, Pei Chuan Ouyang, Chang Yao Hsieh, Jan Seski, Alan Kunschner

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The prevalence of gestational trophoblastic tumors varies widely among different populations: it is lowest in whites (3 to 6 100,000) and highest in Chinese (68 to 202 100,000). This observation suggests that the origin of the disease is different in the two populations. To test this hypothesis, we examined couples in whom the woman developed a gestational trophoblastic tumor in a white population (Pittsburgh) and a Chinese population (Taiwan) for sharing of human leukocyte A, B, DR, and DQ antigens, which we consider markers for sharing of major histocompatibility complex-linked recessive genes affecting both embryogenesis and carcinogenesis. No human leukocyte antigen sharing occurred between partners in Pittsburgh, but there was significant human leukocyte antigen sharing in Taiwan. The latter couples shared human leukocyte antigen B (p < 0.04) and human leukocyte antigen DQ (p < 0.007) and shared three or more human leukocyte A, B, DR, and DQ antigens (p < 0.02) significantly more frequently than did normal coupies. However, there was no increased sharing of any specific human leukocyte antigen allele. These findings support the hypothesis that gestational trophoblastic tumors occur on a sporadic basis in whites and on a genetic basis in Chinese.

Original languageEnglish
Pages (from-to)942-948
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume161
Issue number4
DOIs
Publication statusPublished - Jan 1 1989
Externally publishedYes

Keywords

  • choriocarcinoma
  • genetics of cancer
  • Gestational trophoblastic tumors
  • human leukocyte antigen sharing

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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