Differences between white and Chinese populations in human leukocyte antigen sharing and gestational trophoblastic tumors

Hong Nerng Ho, Thomas J. Gill, Bernard Klionsky, Pei Chuan Ouyang, Chang Yao Hsieh, Jan Seski, Alan Kunschner

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The prevalence of gestational trophoblastic tumors varies widely among different populations: it is lowest in whites (3 to 6 100,000) and highest in Chinese (68 to 202 100,000). This observation suggests that the origin of the disease is different in the two populations. To test this hypothesis, we examined couples in whom the woman developed a gestational trophoblastic tumor in a white population (Pittsburgh) and a Chinese population (Taiwan) for sharing of human leukocyte A, B, DR, and DQ antigens, which we consider markers for sharing of major histocompatibility complex-linked recessive genes affecting both embryogenesis and carcinogenesis. No human leukocyte antigen sharing occurred between partners in Pittsburgh, but there was significant human leukocyte antigen sharing in Taiwan. The latter couples shared human leukocyte antigen B (p < 0.04) and human leukocyte antigen DQ (p < 0.007) and shared three or more human leukocyte A, B, DR, and DQ antigens (p < 0.02) significantly more frequently than did normal coupies. However, there was no increased sharing of any specific human leukocyte antigen allele. These findings support the hypothesis that gestational trophoblastic tumors occur on a sporadic basis in whites and on a genetic basis in Chinese.

Original languageEnglish
Pages (from-to)942-948
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume161
Issue number4
DOIs
Publication statusPublished - Jan 1 1989
Externally publishedYes

Fingerprint

Trophoblastic Neoplasms
Uterine Neoplasms
Choriocarcinoma
HLA Antigens
Marriage
Taiwan
Pregnancy
Population
Leukocytes
Recessive Genes
Antigens
Major Histocompatibility Complex
Embryonic Development
Carcinogenesis
Alleles

Keywords

  • choriocarcinoma
  • genetics of cancer
  • Gestational trophoblastic tumors
  • human leukocyte antigen sharing

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Differences between white and Chinese populations in human leukocyte antigen sharing and gestational trophoblastic tumors. / Ho, Hong Nerng; Gill, Thomas J.; Klionsky, Bernard; Ouyang, Pei Chuan; Hsieh, Chang Yao; Seski, Jan; Kunschner, Alan.

In: American Journal of Obstetrics and Gynecology, Vol. 161, No. 4, 01.01.1989, p. 942-948.

Research output: Contribution to journalArticle

Ho, Hong Nerng ; Gill, Thomas J. ; Klionsky, Bernard ; Ouyang, Pei Chuan ; Hsieh, Chang Yao ; Seski, Jan ; Kunschner, Alan. / Differences between white and Chinese populations in human leukocyte antigen sharing and gestational trophoblastic tumors. In: American Journal of Obstetrics and Gynecology. 1989 ; Vol. 161, No. 4. pp. 942-948.
@article{bbf68270b88c4807b36a88ce4afffbec,
title = "Differences between white and Chinese populations in human leukocyte antigen sharing and gestational trophoblastic tumors",
abstract = "The prevalence of gestational trophoblastic tumors varies widely among different populations: it is lowest in whites (3 to 6 100,000) and highest in Chinese (68 to 202 100,000). This observation suggests that the origin of the disease is different in the two populations. To test this hypothesis, we examined couples in whom the woman developed a gestational trophoblastic tumor in a white population (Pittsburgh) and a Chinese population (Taiwan) for sharing of human leukocyte A, B, DR, and DQ antigens, which we consider markers for sharing of major histocompatibility complex-linked recessive genes affecting both embryogenesis and carcinogenesis. No human leukocyte antigen sharing occurred between partners in Pittsburgh, but there was significant human leukocyte antigen sharing in Taiwan. The latter couples shared human leukocyte antigen B (p < 0.04) and human leukocyte antigen DQ (p < 0.007) and shared three or more human leukocyte A, B, DR, and DQ antigens (p < 0.02) significantly more frequently than did normal coupies. However, there was no increased sharing of any specific human leukocyte antigen allele. These findings support the hypothesis that gestational trophoblastic tumors occur on a sporadic basis in whites and on a genetic basis in Chinese.",
keywords = "choriocarcinoma, genetics of cancer, Gestational trophoblastic tumors, human leukocyte antigen sharing",
author = "Ho, {Hong Nerng} and Gill, {Thomas J.} and Bernard Klionsky and Ouyang, {Pei Chuan} and Hsieh, {Chang Yao} and Jan Seski and Alan Kunschner",
year = "1989",
month = "1",
day = "1",
doi = "10.1016/0002-9378(89)90758-8",
language = "English",
volume = "161",
pages = "942--948",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Differences between white and Chinese populations in human leukocyte antigen sharing and gestational trophoblastic tumors

AU - Ho, Hong Nerng

AU - Gill, Thomas J.

AU - Klionsky, Bernard

AU - Ouyang, Pei Chuan

AU - Hsieh, Chang Yao

AU - Seski, Jan

AU - Kunschner, Alan

PY - 1989/1/1

Y1 - 1989/1/1

N2 - The prevalence of gestational trophoblastic tumors varies widely among different populations: it is lowest in whites (3 to 6 100,000) and highest in Chinese (68 to 202 100,000). This observation suggests that the origin of the disease is different in the two populations. To test this hypothesis, we examined couples in whom the woman developed a gestational trophoblastic tumor in a white population (Pittsburgh) and a Chinese population (Taiwan) for sharing of human leukocyte A, B, DR, and DQ antigens, which we consider markers for sharing of major histocompatibility complex-linked recessive genes affecting both embryogenesis and carcinogenesis. No human leukocyte antigen sharing occurred between partners in Pittsburgh, but there was significant human leukocyte antigen sharing in Taiwan. The latter couples shared human leukocyte antigen B (p < 0.04) and human leukocyte antigen DQ (p < 0.007) and shared three or more human leukocyte A, B, DR, and DQ antigens (p < 0.02) significantly more frequently than did normal coupies. However, there was no increased sharing of any specific human leukocyte antigen allele. These findings support the hypothesis that gestational trophoblastic tumors occur on a sporadic basis in whites and on a genetic basis in Chinese.

AB - The prevalence of gestational trophoblastic tumors varies widely among different populations: it is lowest in whites (3 to 6 100,000) and highest in Chinese (68 to 202 100,000). This observation suggests that the origin of the disease is different in the two populations. To test this hypothesis, we examined couples in whom the woman developed a gestational trophoblastic tumor in a white population (Pittsburgh) and a Chinese population (Taiwan) for sharing of human leukocyte A, B, DR, and DQ antigens, which we consider markers for sharing of major histocompatibility complex-linked recessive genes affecting both embryogenesis and carcinogenesis. No human leukocyte antigen sharing occurred between partners in Pittsburgh, but there was significant human leukocyte antigen sharing in Taiwan. The latter couples shared human leukocyte antigen B (p < 0.04) and human leukocyte antigen DQ (p < 0.007) and shared three or more human leukocyte A, B, DR, and DQ antigens (p < 0.02) significantly more frequently than did normal coupies. However, there was no increased sharing of any specific human leukocyte antigen allele. These findings support the hypothesis that gestational trophoblastic tumors occur on a sporadic basis in whites and on a genetic basis in Chinese.

KW - choriocarcinoma

KW - genetics of cancer

KW - Gestational trophoblastic tumors

KW - human leukocyte antigen sharing

UR - http://www.scopus.com/inward/record.url?scp=0024446282&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024446282&partnerID=8YFLogxK

U2 - 10.1016/0002-9378(89)90758-8

DO - 10.1016/0002-9378(89)90758-8

M3 - Article

C2 - 2552808

AN - SCOPUS:0024446282

VL - 161

SP - 942

EP - 948

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 4

ER -