Dietary rice bran improves the glycemic response in rats with streptozotocin-induced diabetes

M. H. Lai, Y. J. Lin, M. L. Hung, H. H. Cheng

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A 2 × 2 factorial experimental design was employed to evaluate the effect of a fiber-rich rice bran diet on blood glucose, lipid and diabetic nephropathy in streptozotocin (STZ)-induced diabetic rats. Forty male adult Wistar rats were randomly divided into four groups, two of which were injected with nicotinamide and STZ to induce diabetes. Both normal and STZ-diabetic rats were fed AIN-76 diets and rice bran diets (20 g/100 g diet). After 4 weeks of feeding, STZ-diabetic rats both with and without rice bran were significantly (p <0.05) hyperglycemic. Blood fructosamine was ameliorated in rice bran diet-fed STZ-diabetic rats, compared with the baseline. STZ-diabetic rats fed a rice bran diet had a significantly lower blood glucose response than those fed the diet without rice bran. Blood total cholesterol was higher than baseline in AIN-76 diet-fed STZ-diabetic rats, but it had not changed in rice bran diet-fed STZ-diabetic rats. In STZ-diabetic rats, blood creatinine and proteinuria were significantly higher than in nondiabetic rats. These results suggest that a rice bran diet is effective in lowering blood fructosamine and improving the glucose response, but it cannot retard the development of diabetic nephropathy in STZ-diabetic rats.

Original languageEnglish
Pages (from-to)159-170
Number of pages12
JournalNutritional Sciences Journal
Volume26
Issue number3
Publication statusPublished - 2001

Fingerprint

Experimental Diabetes Mellitus
streptozotocin
rice bran
Streptozocin
diabetes
Diet
rats
diet
Fructosamine
diabetic nephropathy
Diabetic Nephropathies
blood
Blood Glucose
blood glucose
Oryza
Niacinamide
nicotinamide
Proteinuria
Wistar Rats
creatinine

Keywords

  • Diabetic rats
  • Glycemic response
  • Rice bran

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Dietary rice bran improves the glycemic response in rats with streptozotocin-induced diabetes. / Lai, M. H.; Lin, Y. J.; Hung, M. L.; Cheng, H. H.

In: Nutritional Sciences Journal, Vol. 26, No. 3, 2001, p. 159-170.

Research output: Contribution to journalArticle

Lai, M. H. ; Lin, Y. J. ; Hung, M. L. ; Cheng, H. H. / Dietary rice bran improves the glycemic response in rats with streptozotocin-induced diabetes. In: Nutritional Sciences Journal. 2001 ; Vol. 26, No. 3. pp. 159-170.
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