Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan

Jiun Rong Chen, Shiou Fung Hsu, Cheng Dien Hsu, Lih Hsueh Hwang, Suh Ching Yang

Research output: Contribution to journalArticle

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Abstract

Nutritional factors may be relative to attention-deficit hyperactive disorder (ADHD), although the pathogenic mechanism is still unknown. Based on the work of others, we hypothesized that children with ADHD have altered dietary patterns and fatty acid metabolism. Therefore, the aim of this study was to evaluate dietary patterns and the blood fatty acid composition in children with ADHD in the Taipei area of Taiwan. The present study found that 58 subjects with ADHD (average age 8.5 years) had significantly higher intakes of iron and vitamin C compared to those of 52 control subjects (average age 7.9 years) (P <0.05). The blood total protein content in subjects with ADHD was significantly lower than that in control subjects (P <0.05). On the other hand, children with ADHD had significantly higher blood iron levels compared to the control children (P <0.05). Additionally, plasma γ-linolenic acid (18:3 n-6) in children with ADHD was higher than that in control children (P <0.05). Concerning the composition of other fatty acids in the phospholipid isolated from red blood cell (RBC) membranes, oleic acid (18:1n-9) was significantly higher, whereas nervonic acid (24:1n-9), linoleic acid (18:2n-6), arachidonic acid (20:4n-6), and docosahexaenoic acid (22:6n-3) were significantly lower in subjects with ADHD (P <0.05). Our results suggest that there were no differences in dietary patterns of these children with ADHD except for the intake of iron and vitamin C; however, the fatty acid composition of phospholipid from RBC membranes in the ADHD children differed from that of the normal children.

Original languageEnglish
Pages (from-to)467-472
Number of pages6
JournalJournal of Nutritional Biochemistry
Volume15
Issue number8
DOIs
Publication statusPublished - Aug 2004

Fingerprint

Attention Deficit Disorder with Hyperactivity
Taiwan
Blood
Fatty Acids
Chemical analysis
Iron
Cell membranes
Ascorbic Acid
Phospholipids
alpha-Linolenic Acid
Docosahexaenoic Acids
Linoleic Acid
Oleic Acid
Arachidonic Acid
Metabolism
Erythrocytes
Cell Membrane
Plasmas
Blood Proteins
Proteins

Keywords

  • Attention-deficit hyperactivity disorder (ADHD)
  • Blood fatty acid composition
  • Dietary pattern

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan. / Chen, Jiun Rong; Hsu, Shiou Fung; Hsu, Cheng Dien; Hwang, Lih Hsueh; Yang, Suh Ching.

In: Journal of Nutritional Biochemistry, Vol. 15, No. 8, 08.2004, p. 467-472.

Research output: Contribution to journalArticle

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