Diagnostic value of EBUS-TBNA for lung cancer with non-enlarged lymph nodes: A study in a Tuberculosis-Endemic Country

Chih Hsi Kuo, Hao Cheng Chen, Fu Tsai Chung, Yu Lun Lo, Kang Yun Lee, Chih Wei Wang, Wen Han Kuo, Tzu Chen Yen, Han Pin Kuo

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: In tuberculosis (TB)-endemic areas, contrast-enhanced computed tomography (CT) and positron emission tomography (PET) findings of lung cancer patients with non-enlarged lymph nodes are frequently discrepant. Endobronchial ultrasound-guided transbronchial aspiration (EBUS-TBNA) enables real-time nodal sampling, and thereby improves nodal diagnosis accuracy. This study aimed to compare the accuracy of nodal diagnosis by using EBUS-TBNA, and PET. Methods: We studied 43 lung cancer patients with CT-defined non-enlarged mediastinal and hilar lymph nodes and examined 78 lymph nodes using EBUS-TBNA. Results: The sensitivity, specificity, positive predictive value, and negative predictive value of EBUS-TBNA were 80.6%, 100%, 100%, and 85.7%, respectively. PET had low specificity (18.9%) and a low positive predictive value (44.4%). The diagnostic accuracy of EBUS-TBNA was higher than that of PET (91% vs. 47.4%; p

Original languageEnglish
Article numbere16877
JournalPLoS One
Volume6
Issue number2
DOIs
Publication statusPublished - 2011
Externally publishedYes

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positron-emission tomography
disease diagnosis
lung neoplasms
tuberculosis
Positron emission tomography
Positron-Emission Tomography
lymph nodes
Lung Neoplasms
Tuberculosis
Lymph Nodes
Ultrasonics
computed tomography
Tomography
Sensitivity and Specificity
Sampling
sampling

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Diagnostic value of EBUS-TBNA for lung cancer with non-enlarged lymph nodes : A study in a Tuberculosis-Endemic Country. / Kuo, Chih Hsi; Chen, Hao Cheng; Chung, Fu Tsai; Lo, Yu Lun; Lee, Kang Yun; Wang, Chih Wei; Kuo, Wen Han; Yen, Tzu Chen; Kuo, Han Pin.

In: PLoS One, Vol. 6, No. 2, e16877, 2011.

Research output: Contribution to journalArticle

Kuo, Chih Hsi ; Chen, Hao Cheng ; Chung, Fu Tsai ; Lo, Yu Lun ; Lee, Kang Yun ; Wang, Chih Wei ; Kuo, Wen Han ; Yen, Tzu Chen ; Kuo, Han Pin. / Diagnostic value of EBUS-TBNA for lung cancer with non-enlarged lymph nodes : A study in a Tuberculosis-Endemic Country. In: PLoS One. 2011 ; Vol. 6, No. 2.
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abstract = "Background: In tuberculosis (TB)-endemic areas, contrast-enhanced computed tomography (CT) and positron emission tomography (PET) findings of lung cancer patients with non-enlarged lymph nodes are frequently discrepant. Endobronchial ultrasound-guided transbronchial aspiration (EBUS-TBNA) enables real-time nodal sampling, and thereby improves nodal diagnosis accuracy. This study aimed to compare the accuracy of nodal diagnosis by using EBUS-TBNA, and PET. Methods: We studied 43 lung cancer patients with CT-defined non-enlarged mediastinal and hilar lymph nodes and examined 78 lymph nodes using EBUS-TBNA. Results: The sensitivity, specificity, positive predictive value, and negative predictive value of EBUS-TBNA were 80.6{\%}, 100{\%}, 100{\%}, and 85.7{\%}, respectively. PET had low specificity (18.9{\%}) and a low positive predictive value (44.4{\%}). The diagnostic accuracy of EBUS-TBNA was higher than that of PET (91{\%} vs. 47.4{\%}; p",
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