Diagnosis of thyroid metastasis in cancer patients with thyroid mass by fine needle aspiration cytology and ultrasonography

Shih Yi Lin, Wayne Heuy Herng Sheu, Ming Chen Chang, Kam Tsum Tang, Tin I. Lee, Hong Da Lin

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background. Thyroid metastasis is generally thought to be infrequent. To evaluate its occurrence, fine needle aspiration cytology and ultrasound of the thyroid gland were performed in nonthyroid cancer patients with thyroid mass. Methods. A total of 20 nonthyroid cancer patients (6 males and 14 females with a mean age of 55 ± 7 years) with thyroid mass were examined with thyroid ultrasound and fine needle aspiration cytology. Their underlying malignancies included lung cancer in 10 patients, breast cancer in 7 patients, cervical cancer in 2 patients and colon cancer in 1 patient. Results. Thyroid metastases were diagnosed in 4 patients (20%), 2 with breast cancer and 2 with lung cancer. For 3 of them, thyroid ultrasound showed solitary hypoechoic nodule, and in 1 case, multiple nodular lesions were demonstrated in each lobe. In addition, neck lymph nodes were noted in 3 patients. In the remaining 16 cancer patients, thyroid ultrasound showed either multiple or solitary nodular goiter change with no neck lymph node involvement. Fine needle aspiration cytology (FNAC) yielded nonthyroid adenocarcinoma in 4 metastatic cases. The 2 breast cancer patients received finally total thyroidectomy and were still alive 1 year after operation. While in the other 2 lung cancer cases, only supportive treatment were given due to advanced stages and the patients died within months. Conclusions. Thyroid metastases could occur at a high frequency in nonthyroid cancer patients with thyroid mass from our small series. By combining FNAC with ultrasound, a clinical diagnosis of thyroid metastasis is attainable in cancer patients with thyroid mass.

Original languageEnglish
Pages (from-to)101-105
Number of pages5
JournalChinese Medical Journal (Taipei)
Volume65
Issue number3
Publication statusPublished - 2002
Externally publishedYes

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Fine Needle Biopsy
Cell Biology
Ultrasonography
Thyroid Gland
Neoplasm Metastasis
Neoplasms
Lung Neoplasms
Breast Neoplasms
Neck
Lymph Nodes
Nodular Goiter
Thyroidectomy
Thyroid Neoplasms
Uterine Cervical Neoplasms
Colonic Neoplasms
Adenocarcinoma

Keywords

  • Fine needle aspiration cytology
  • Thyroid metastasis
  • Ultrasonography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Diagnosis of thyroid metastasis in cancer patients with thyroid mass by fine needle aspiration cytology and ultrasonography. / Lin, Shih Yi; Sheu, Wayne Heuy Herng; Chang, Ming Chen; Tang, Kam Tsum; Lee, Tin I.; Lin, Hong Da.

In: Chinese Medical Journal (Taipei), Vol. 65, No. 3, 2002, p. 101-105.

Research output: Contribution to journalArticle

Lin, Shih Yi ; Sheu, Wayne Heuy Herng ; Chang, Ming Chen ; Tang, Kam Tsum ; Lee, Tin I. ; Lin, Hong Da. / Diagnosis of thyroid metastasis in cancer patients with thyroid mass by fine needle aspiration cytology and ultrasonography. In: Chinese Medical Journal (Taipei). 2002 ; Vol. 65, No. 3. pp. 101-105.
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N2 - Background. Thyroid metastasis is generally thought to be infrequent. To evaluate its occurrence, fine needle aspiration cytology and ultrasound of the thyroid gland were performed in nonthyroid cancer patients with thyroid mass. Methods. A total of 20 nonthyroid cancer patients (6 males and 14 females with a mean age of 55 ± 7 years) with thyroid mass were examined with thyroid ultrasound and fine needle aspiration cytology. Their underlying malignancies included lung cancer in 10 patients, breast cancer in 7 patients, cervical cancer in 2 patients and colon cancer in 1 patient. Results. Thyroid metastases were diagnosed in 4 patients (20%), 2 with breast cancer and 2 with lung cancer. For 3 of them, thyroid ultrasound showed solitary hypoechoic nodule, and in 1 case, multiple nodular lesions were demonstrated in each lobe. In addition, neck lymph nodes were noted in 3 patients. In the remaining 16 cancer patients, thyroid ultrasound showed either multiple or solitary nodular goiter change with no neck lymph node involvement. Fine needle aspiration cytology (FNAC) yielded nonthyroid adenocarcinoma in 4 metastatic cases. The 2 breast cancer patients received finally total thyroidectomy and were still alive 1 year after operation. While in the other 2 lung cancer cases, only supportive treatment were given due to advanced stages and the patients died within months. Conclusions. Thyroid metastases could occur at a high frequency in nonthyroid cancer patients with thyroid mass from our small series. By combining FNAC with ultrasound, a clinical diagnosis of thyroid metastasis is attainable in cancer patients with thyroid mass.

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