Diabetic retinopathy as a risk factor for chronic kidney disease progression: A multicenter case–control study in Taiwan

Hsin Ting Lin, Cai Mei Zheng, Yun Chun Wu, Yun Hsiang Chang, Jiann Torng Chen, Chang Min Liang, Tian Jong Chang, Jing Quan Zheng, Ming Cheng Tai, Yuh Feng Lin

Research output: Contribution to journalArticle

Abstract

It has rarely been studied whether the presence and severity of diabetic retinopathy (DR) could influence the renal disease progression among all chronic kidney disease (CKD) diabetic patients. This study investigates the characteristics of diabetic patients, with different stages of chronic kidney disease (CKD), according to the occurrence of diabetic retinopathy and determines the influence of retinopathy in the deterioration of renal function. We conduct a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of the CKD project (2008–2013) and the National Health Insurance Research Database (NHIRD) (2001–2013). A total of 4050 diabetic patients with CKD, 20–85 years of age, from 14 hospitals and the community are included in this study. As compared to CKD patients without DR, CKD patients with DR have a lower baseline estimated glomerular filtration rate (eGFR) (39.17 ± 30.36 mL/min per 1.73 m 2 vs. 54.38 ± 33.67 mL/min per 1.73 m 2 ); poorer glycemic control (higher glycated hemoglobin (HbA1c) 7.85 ± 4.97 vs. 7.29 ± 4.02, p < 0.01); higher proteinuria (urine protein-to-creatinine ratio (UPCR)1.94 ± 2.96 g/dL vs. 0.91 ± 2.11 g/dL, p < 0.01); more anemia (Hb 11.22 ± 2.43 g/dL vs. 12.39 ± 3.85 g/dL, p < 0.01), and more hypoalbuminemia (3.88 ± 0.95 g/dL vs. 4.16 ± 1.74 g/dL, p < 0.01). Later stage (stage 3b–5) CKD patients with DR had significantly higher CKD progression compared with patients without DR (OR (odds ratio) 1.66 (1.36–2.02)). Patients with proliferative DR had significantly higher CKD progression events compared to patients with non-proliferative DR (OR 2.18 (1.71–2.78)). The presence and severity of DR is a risk factor for CKD progression among our Taiwanese CKD patients with diabetes. Prevention and early detection of DR are important and DR should be routinely screened as early as possible among diabetic CKD patients.

Original languageEnglish
Article number509
JournalNutrients
Volume11
Issue number3
DOIs
Publication statusPublished - Mar 1 2019

Keywords

  • Chronic kidney disease (CKD) cohort
  • Diabetic retinopathy (DR)
  • Estimated glomerular filtration rate
  • National Health Insurance Research Database
  • Progression of CKD
  • Humans
  • Middle Aged
  • Risk Factors
  • Male
  • Renal Insufficiency, Chronic/pathology
  • Case-Control Studies
  • Taiwan
  • Female
  • Aged
  • Odds Ratio
  • Diabetic Retinopathy/complications
  • Cohort Studies

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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