Diabetic ketoacidosis and persistent hyperglycemia as long-term complications of L-asparaginase-induced pancreatitis

Yu Juei Hsu, Yeu Chin Chen, Ching Liang Ho, Woei Yau Kao, Tsu Yi Chao

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Diabetic ketoacidosis (DKA) and pancreatic pseudocysts are rare complications following treatment of hematological malignancies with L-asparaginase (L-asp). Persistent hyperglycemia with recurrent DKA presenting as a long-term complication of L-asp-induced pancreatitis is even rarer. A 21 -year-old man with pre-B-type acute lymphoblastic leukemia (ALL) developed pancreatic pseudocysts, DKA and persistent hyperglycemia after L-asp therapy. The patient was treated with oral hypoglycemic agents (OHA) for sugar control thereafter. Ten months later, another episode of DKA developed during relapsed ALL without having obvious precipitating factors. Insulin was then instituted for control of his blood sugar until death. The leukemic process may play some role in glucose homeostasis and may be considered as a precipitating factor for DKA. The patient finally died of disease progression of ALL and sepsis 2 years after the initial diagnosis of ALL.

Original languageEnglish
Pages (from-to)441-445
Number of pages5
JournalChinese Medical Journal (Taipei)
Volume65
Issue number9
Publication statusPublished - Sep 1 2002
Externally publishedYes

Fingerprint

Asparaginase
Diabetic Ketoacidosis
Hyperglycemia
Pancreatitis
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pancreatic Pseudocyst
Precipitating Factors
Hematologic Neoplasms
Hypoglycemic Agents
Disease Progression
Blood Glucose
Sepsis
Homeostasis
Insulin
Glucose
Therapeutics

Keywords

  • Asparaginase
  • Diabetic Ketoacidosis
  • Hyperglycemia
  • Pancreatitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Diabetic ketoacidosis and persistent hyperglycemia as long-term complications of L-asparaginase-induced pancreatitis. / Hsu, Yu Juei; Chen, Yeu Chin; Ho, Ching Liang; Kao, Woei Yau; Chao, Tsu Yi.

In: Chinese Medical Journal (Taipei), Vol. 65, No. 9, 01.09.2002, p. 441-445.

Research output: Contribution to journalArticle

Hsu, Yu Juei ; Chen, Yeu Chin ; Ho, Ching Liang ; Kao, Woei Yau ; Chao, Tsu Yi. / Diabetic ketoacidosis and persistent hyperglycemia as long-term complications of L-asparaginase-induced pancreatitis. In: Chinese Medical Journal (Taipei). 2002 ; Vol. 65, No. 9. pp. 441-445.
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