Diabetes worsens the surgical outcomes in cirrhotic patients with hepatocellular carcinoma

Chin Tsung Ting, Ran Chou Chen, Chien Cheng Chen, Mao Ho Liu, Dachen Chu, Nai Wen Kuo

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Diabetes is a known risk factor for developing hepatocellular carcinoma (HCC). Reported rates of diabetes are higher in chronic hepatitis, cirrhosis and HCC patients. However, its effects on postoperative recurrence and survival with HCC are controversial. This study offers a retrospective analysis of the impacts of diabetes on postoperative recurrence and survival in patients with cirrhosis and HCC. A total of 389 cirrhotic patients who underwent curative resection for primary HCC at our institution between January 2000 and December 2008 were enrolled. Of them, 272 (70%) patients were classified into a non-diabetes group and 117 (30%) patients into the diabetes group. The diabetes group was divided into an oral hypoglycemic agent (OHA) control group (n = 100) and an insulin control group (n = 17). The result indicates that the diabetes group had a higher postoperative recurrence rate and poorer long-term survival rate (p = 0.001 vs. 0.01). There was no significant difference in recurrence-free survival rate between the OHA control group and the insulin control group (p = 0.17). The insulin control group had a poorer long-term surgical outcome than the OHA control group (p = 0.035). In conclusion, our results suggest that diabetes is an independent risk factor for postoperative recurrence and surgical survival of cirrhotic HCC patients. Cirrhotic HCC patients with diabetes who received hepatic resection should be closely followed-up for postoperative recurrence and long-term outcome. Moreover, an effective peri-operative sugar control planning in HCC patients with diabetes should be established.

Original languageEnglish
Pages (from-to)73-81
Number of pages9
JournalTohoku Journal of Experimental Medicine
Volume227
Issue number1
DOIs
Publication statusPublished - 2012

Fingerprint

Medical problems
Hepatocellular Carcinoma
Recurrence
Control Groups
Hypoglycemic Agents
Insulin
Survival
Fibrosis
Survival Rate
Chronic Hepatitis
Sugars
Planning
Liver

Keywords

  • Diabetes mellitus
  • Hepatocellular carcinoma
  • Insulin
  • Liver cirrhosis
  • Oral hypoglycemic agent

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Diabetes worsens the surgical outcomes in cirrhotic patients with hepatocellular carcinoma. / Ting, Chin Tsung; Chen, Ran Chou; Chen, Chien Cheng; Liu, Mao Ho; Chu, Dachen; Kuo, Nai Wen.

In: Tohoku Journal of Experimental Medicine, Vol. 227, No. 1, 2012, p. 73-81.

Research output: Contribution to journalArticle

Ting, Chin Tsung ; Chen, Ran Chou ; Chen, Chien Cheng ; Liu, Mao Ho ; Chu, Dachen ; Kuo, Nai Wen. / Diabetes worsens the surgical outcomes in cirrhotic patients with hepatocellular carcinoma. In: Tohoku Journal of Experimental Medicine. 2012 ; Vol. 227, No. 1. pp. 73-81.
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