Diabetes mellitus and risk of subsequent depression

A longitudinal study

Yi Min Hsu, Li Ting Su, Hui Mei Chang, Fung Chang Sung, Shu Yu Lyu, Pei Chun Chen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Findings of previous studies on the association between diabetes and the risk of depression are contradictory. Furthermore, much less is known concerning the association among young adults. Objective: To investigate whether diabetes is associated with an increased risk of subsequent development of depression, with emphasis on age-specific variations. Design: A cohort study. Setting: Claims data of one million subjects randomly selected from 23 million people covered by the Taiwan National Health Insurance program. Participants: From the claims data, we identified 14,048 patients aged ≥20. years with newly diagnosed diabetes in 2000-2002 and randomly selected 55,608 non-diabetic subjects for comparison, that were frequency-matched by calendar year, age, and gender. Incidence rates of depression to the end of 2007 were identified, and risks were compared between the two groups. Results: The incidence of depression was 1.80-times higher in the diabetic group than in nondiabetic subjects over a median follow-up of 6.5. years (adjusted hazard ratio [HR]. =. 1.46, 95% confidence interval [CI]: 1.24-1.71). Age-specific HRs for incidence of depression in relation to diabetes were not statistically different between the patient subgroups aged 20-39, 40-49, 50-59, 60-69 and ≥70. years (. p value for age-diabetes interaction. =. 0.33). Stratified analyses showed that the association was much stronger for subjects without comorbid cardiovascular disease than for those with this comorbidity. Insulin treatment was associated with a 43% reduced risk of depression in diabetic patients. Conclusions: In this population-based study, diabetic patients were at a higher risk for subsequent depression. Adequate treatment reduced the risk.

Original languageEnglish
Pages (from-to)437-444
Number of pages8
JournalInternational Journal of Nursing Studies
Volume49
Issue number4
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Longitudinal Studies
Diabetes Mellitus
National Health Programs
Incidence
Taiwan
Comorbidity
Young Adult
Cohort Studies
Cardiovascular Diseases
Confidence Intervals
Insulin
Therapeutics
Population

Keywords

  • Depression
  • Diabetes mellitus
  • Incidence
  • Longitudinal studies

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Diabetes mellitus and risk of subsequent depression : A longitudinal study. / Hsu, Yi Min; Su, Li Ting; Chang, Hui Mei; Sung, Fung Chang; Lyu, Shu Yu; Chen, Pei Chun.

In: International Journal of Nursing Studies, Vol. 49, No. 4, 04.2012, p. 437-444.

Research output: Contribution to journalArticle

Hsu, Yi Min ; Su, Li Ting ; Chang, Hui Mei ; Sung, Fung Chang ; Lyu, Shu Yu ; Chen, Pei Chun. / Diabetes mellitus and risk of subsequent depression : A longitudinal study. In: International Journal of Nursing Studies. 2012 ; Vol. 49, No. 4. pp. 437-444.
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