Abstract

Patients with bipolar disorder (BD) are at high risk for developing cardiovascular diseases (CVDs) during aging process. However, investigations are lacking regarding the risk factors for CVDs specific to BD patients. The aim of this study was to examine the relationship between CVDs and traditional risk factors in association with the characteristics of BD in older age. Totally, we recruited 124 patients with BD-I (DSM-IV) who had at least one psychiatric admission and cardiologist-confirmed CVD diagnosis (ICD-9 code 401–414) at mean age of 61.7+4.9 years. Each case subject was matched with one BD-I patient without CVDs based on age, sex, and date of the most recent psychiatric admission (+2 years). Clinical data were obtained by retrospectively reviewing the medical record. A multiple logistic regression model showed that not only traditional risk factor (e.g., diabetes mellitus) but also non-traditional one associated with BD (e.g., first episode mania) significantly increased the risk of CVDs. Given the limitation of this cross-sectional study, longitudinal investigations are needed to elucidate the contributions of both traditional risk factors and the BD characteristics for CVD risk in patients with BD.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalPsychiatry Research
Volume249
DOIs
Publication statusPublished - Mar 1 2017

Fingerprint

Bipolar Disorder
Diabetes Mellitus
Cardiovascular Diseases
International Classification of Diseases
Psychiatry
Logistic Models
Diagnostic and Statistical Manual of Mental Disorders
Medical Records
Cross-Sectional Studies

Keywords

  • Bipolar disorder
  • Diabetes mellitus
  • Hypertension
  • Ischemic heart disease
  • Mania
  • Obesity

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

@article{88c385b3a6a94d4bb4fd68c312665f74,
title = "Diabetes mellitus and first episode mania associated with cardiovascular diseases in patients with older-age bipolar disorder",
abstract = "Patients with bipolar disorder (BD) are at high risk for developing cardiovascular diseases (CVDs) during aging process. However, investigations are lacking regarding the risk factors for CVDs specific to BD patients. The aim of this study was to examine the relationship between CVDs and traditional risk factors in association with the characteristics of BD in older age. Totally, we recruited 124 patients with BD-I (DSM-IV) who had at least one psychiatric admission and cardiologist-confirmed CVD diagnosis (ICD-9 code 401–414) at mean age of 61.7+4.9 years. Each case subject was matched with one BD-I patient without CVDs based on age, sex, and date of the most recent psychiatric admission (+2 years). Clinical data were obtained by retrospectively reviewing the medical record. A multiple logistic regression model showed that not only traditional risk factor (e.g., diabetes mellitus) but also non-traditional one associated with BD (e.g., first episode mania) significantly increased the risk of CVDs. Given the limitation of this cross-sectional study, longitudinal investigations are needed to elucidate the contributions of both traditional risk factors and the BD characteristics for CVD risk in patients with BD.",
keywords = "Bipolar disorder, Diabetes mellitus, Hypertension, Ischemic heart disease, Mania, Obesity",
author = "Chen, {Pao Huan} and Chang, {Chi Kang} and Shuo-Ju Chiang and Yen-Kuang Lin and Shang-Ying Tsai and Shou-Hung Huang",
year = "2017",
month = "3",
day = "1",
doi = "10.1016/j.psychres.2017.01.004",
language = "English",
volume = "249",
pages = "65--69",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Diabetes mellitus and first episode mania associated with cardiovascular diseases in patients with older-age bipolar disorder

AU - Chen, Pao Huan

AU - Chang, Chi Kang

AU - Chiang, Shuo-Ju

AU - Lin, Yen-Kuang

AU - Tsai, Shang-Ying

AU - Huang, Shou-Hung

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Patients with bipolar disorder (BD) are at high risk for developing cardiovascular diseases (CVDs) during aging process. However, investigations are lacking regarding the risk factors for CVDs specific to BD patients. The aim of this study was to examine the relationship between CVDs and traditional risk factors in association with the characteristics of BD in older age. Totally, we recruited 124 patients with BD-I (DSM-IV) who had at least one psychiatric admission and cardiologist-confirmed CVD diagnosis (ICD-9 code 401–414) at mean age of 61.7+4.9 years. Each case subject was matched with one BD-I patient without CVDs based on age, sex, and date of the most recent psychiatric admission (+2 years). Clinical data were obtained by retrospectively reviewing the medical record. A multiple logistic regression model showed that not only traditional risk factor (e.g., diabetes mellitus) but also non-traditional one associated with BD (e.g., first episode mania) significantly increased the risk of CVDs. Given the limitation of this cross-sectional study, longitudinal investigations are needed to elucidate the contributions of both traditional risk factors and the BD characteristics for CVD risk in patients with BD.

AB - Patients with bipolar disorder (BD) are at high risk for developing cardiovascular diseases (CVDs) during aging process. However, investigations are lacking regarding the risk factors for CVDs specific to BD patients. The aim of this study was to examine the relationship between CVDs and traditional risk factors in association with the characteristics of BD in older age. Totally, we recruited 124 patients with BD-I (DSM-IV) who had at least one psychiatric admission and cardiologist-confirmed CVD diagnosis (ICD-9 code 401–414) at mean age of 61.7+4.9 years. Each case subject was matched with one BD-I patient without CVDs based on age, sex, and date of the most recent psychiatric admission (+2 years). Clinical data were obtained by retrospectively reviewing the medical record. A multiple logistic regression model showed that not only traditional risk factor (e.g., diabetes mellitus) but also non-traditional one associated with BD (e.g., first episode mania) significantly increased the risk of CVDs. Given the limitation of this cross-sectional study, longitudinal investigations are needed to elucidate the contributions of both traditional risk factors and the BD characteristics for CVD risk in patients with BD.

KW - Bipolar disorder

KW - Diabetes mellitus

KW - Hypertension

KW - Ischemic heart disease

KW - Mania

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=85008656668&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85008656668&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2017.01.004

DO - 10.1016/j.psychres.2017.01.004

M3 - Article

C2 - 28073032

AN - SCOPUS:85008656668

VL - 249

SP - 65

EP - 69

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

ER -