Developmental origin of postnatal cardiomyogenic progenitor cells

Yuan-Hung Liu, Ling-Ping Lai, Shih-Yun Huang, Yi-Shuan Lin, Shinn-Chih Wu, Chih-Jen Chou, Jiunn-Lee Lin

Research output: Contribution to journalArticle

Abstract

AIM: To trace the cell origin of the cells involved in postnatal cardiomyogenesis.

MATERIALS & METHODS: Nkx2.5 enhancer-eGFP (Nkx2.5 enh-eGFP) mice were used to test the cardiomyogenic potential of Nkx2.5 enhancer-expressing cells. By analyzing Cre excision of activated Nkx2.5-eGFP+ cells from different lineage-Cre/Nkx2.5 enh-eGFP/ROSA26 reporter mice, we traced the developmental origin of Nkx2.5 enhancer-expressing cells.

RESULTS: Nkx2.5 enhancer-expressing cells could differentiate into striated cardiomyocytes both in vitro and in vivo. Nkx2.5-eGFP+ cells increased remarkably after experimental myocardial infarction (MI). The post-MI Nkx2.5-eGFP+ cells originated from the embryonic epicardial cells, not from the pre-existing cardiomyocytes, endothelial cells, cardiac neural crest cells or perinatal/postnatal epicardial cells.

CONCLUSION: Postnatal Nkx2.5 enhancer-expressing cells are cardiomyogenic progenitor cells and originate from embryonic epicardium-derived cells.

Original languageEnglish
Pages (from-to)FSO120
JournalFuture Oncology
Volume2
Issue number2
DOIs
Publication statusPublished - Jun 2016
Externally publishedYes

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Stem Cells
Cardiac Myocytes
Myocardial Infarction
Neural Crest
Pericardium
Cell Lineage
Endothelial Cells

Cite this

Liu, Y-H., Lai, L-P., Huang, S-Y., Lin, Y-S., Wu, S-C., Chou, C-J., & Lin, J-L. (2016). Developmental origin of postnatal cardiomyogenic progenitor cells. Future Oncology, 2(2), FSO120. https://doi.org/10.4155/fsoa-2016-0006

Developmental origin of postnatal cardiomyogenic progenitor cells. / Liu, Yuan-Hung; Lai, Ling-Ping; Huang, Shih-Yun; Lin, Yi-Shuan; Wu, Shinn-Chih; Chou, Chih-Jen; Lin, Jiunn-Lee.

In: Future Oncology, Vol. 2, No. 2, 06.2016, p. FSO120.

Research output: Contribution to journalArticle

Liu, Y-H, Lai, L-P, Huang, S-Y, Lin, Y-S, Wu, S-C, Chou, C-J & Lin, J-L 2016, 'Developmental origin of postnatal cardiomyogenic progenitor cells', Future Oncology, vol. 2, no. 2, pp. FSO120. https://doi.org/10.4155/fsoa-2016-0006
Liu Y-H, Lai L-P, Huang S-Y, Lin Y-S, Wu S-C, Chou C-J et al. Developmental origin of postnatal cardiomyogenic progenitor cells. Future Oncology. 2016 Jun;2(2):FSO120. https://doi.org/10.4155/fsoa-2016-0006
Liu, Yuan-Hung ; Lai, Ling-Ping ; Huang, Shih-Yun ; Lin, Yi-Shuan ; Wu, Shinn-Chih ; Chou, Chih-Jen ; Lin, Jiunn-Lee. / Developmental origin of postnatal cardiomyogenic progenitor cells. In: Future Oncology. 2016 ; Vol. 2, No. 2. pp. FSO120.
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