Development of swellable local implants of a polyethyleneimine-poly(vinyl pyrrolidone) (PEI-PVP) hydrogel as a socket filler

Ching Wen Chang, Hsiu O. Ho, Yi June Lo, Sheng Yang Lee, You Ren Yang, Ming Thau Sheu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In this study, hydrogels composed of polyethyleneimine (PEI) and poly(vinyl pyrrolidone) K90 (PVP) cross-linked with various concentrations (0, 0.125, 0.25 and 0.5%) of glutaraldehyde were evaluated as a hydrogel filler for the local delivery of lidocaine after tooth extraction. The drug-release kinetics, swellability, cy-totoxicity and wound healing after tooth extraction of these non-cross-linked and cross-linked PEI-PVP hydrogels were examined in male beagles and compared to values using Spongostan®. Results demonstrated that the extent of cross-linking influenced the swelling of the resulting hydrogel, but the drug-release rates were similar. No significant changes were observed in gingival fibroblasts in contact with the PEI- PVP hydrogels or Spongostan®. In the in vivo study, PEI-PVP hydrogels showed good retention in the socket for 2 days and showed comparable wound-healing rates within 2 weeks with those of Spongostan®. In conclusion, PEI-PVP hydrogels are suitable for use as socket-dressing materials, and the release of local anaesthesia from PEI-PVP hydrogels can be sustained for a desirable period of time to prevent pain after a tooth extraction.

Original languageEnglish
Pages (from-to)2171-2184
Number of pages14
JournalJournal of Biomaterials Science, Polymer Edition
Volume23
Issue number17
DOIs
Publication statusPublished - 2012

Fingerprint

Pyrrolidinones
Polyethyleneimine
Hydrogels
Hydrogel
Fibrin Foam
Fillers
Tooth Extraction
Wound Healing
Glutaral
Local Anesthesia
Fibroblasts
Bandages
Lidocaine
Pharmaceutical Preparations
Swelling
Pharmacokinetics
Pain
Kinetics

Keywords

  • Hydrogel
  • Poly(vinyl pyrrolidone)
  • Polyethyleneimine
  • Socket filler

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering

Cite this

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title = "Development of swellable local implants of a polyethyleneimine-poly(vinyl pyrrolidone) (PEI-PVP) hydrogel as a socket filler",
abstract = "In this study, hydrogels composed of polyethyleneimine (PEI) and poly(vinyl pyrrolidone) K90 (PVP) cross-linked with various concentrations (0, 0.125, 0.25 and 0.5{\%}) of glutaraldehyde were evaluated as a hydrogel filler for the local delivery of lidocaine after tooth extraction. The drug-release kinetics, swellability, cy-totoxicity and wound healing after tooth extraction of these non-cross-linked and cross-linked PEI-PVP hydrogels were examined in male beagles and compared to values using Spongostan{\circledR}. Results demonstrated that the extent of cross-linking influenced the swelling of the resulting hydrogel, but the drug-release rates were similar. No significant changes were observed in gingival fibroblasts in contact with the PEI- PVP hydrogels or Spongostan{\circledR}. In the in vivo study, PEI-PVP hydrogels showed good retention in the socket for 2 days and showed comparable wound-healing rates within 2 weeks with those of Spongostan{\circledR}. In conclusion, PEI-PVP hydrogels are suitable for use as socket-dressing materials, and the release of local anaesthesia from PEI-PVP hydrogels can be sustained for a desirable period of time to prevent pain after a tooth extraction.",
keywords = "Hydrogel, Poly(vinyl pyrrolidone), Polyethyleneimine, Socket filler",
author = "Chang, {Ching Wen} and Ho, {Hsiu O.} and Lo, {Yi June} and Lee, {Sheng Yang} and Yang, {You Ren} and Sheu, {Ming Thau}",
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T1 - Development of swellable local implants of a polyethyleneimine-poly(vinyl pyrrolidone) (PEI-PVP) hydrogel as a socket filler

AU - Chang, Ching Wen

AU - Ho, Hsiu O.

AU - Lo, Yi June

AU - Lee, Sheng Yang

AU - Yang, You Ren

AU - Sheu, Ming Thau

PY - 2012

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AB - In this study, hydrogels composed of polyethyleneimine (PEI) and poly(vinyl pyrrolidone) K90 (PVP) cross-linked with various concentrations (0, 0.125, 0.25 and 0.5%) of glutaraldehyde were evaluated as a hydrogel filler for the local delivery of lidocaine after tooth extraction. The drug-release kinetics, swellability, cy-totoxicity and wound healing after tooth extraction of these non-cross-linked and cross-linked PEI-PVP hydrogels were examined in male beagles and compared to values using Spongostan®. Results demonstrated that the extent of cross-linking influenced the swelling of the resulting hydrogel, but the drug-release rates were similar. No significant changes were observed in gingival fibroblasts in contact with the PEI- PVP hydrogels or Spongostan®. In the in vivo study, PEI-PVP hydrogels showed good retention in the socket for 2 days and showed comparable wound-healing rates within 2 weeks with those of Spongostan®. In conclusion, PEI-PVP hydrogels are suitable for use as socket-dressing materials, and the release of local anaesthesia from PEI-PVP hydrogels can be sustained for a desirable period of time to prevent pain after a tooth extraction.

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