Abstract
In this study, hydrogels composed of polyethyleneimine (PEI) and poly(vinyl pyrrolidone) K90 (PVP) cross-linked with various concentrations (0, 0.125, 0.25 and 0.5%) of glutaraldehyde were evaluated as a hydrogel filler for the local delivery of lidocaine after tooth extraction. The drug-release kinetics, swellability, cy-totoxicity and wound healing after tooth extraction of these non-cross-linked and cross-linked PEI-PVP hydrogels were examined in male beagles and compared to values using Spongostan®. Results demonstrated that the extent of cross-linking influenced the swelling of the resulting hydrogel, but the drug-release rates were similar. No significant changes were observed in gingival fibroblasts in contact with the PEI- PVP hydrogels or Spongostan®. In the in vivo study, PEI-PVP hydrogels showed good retention in the socket for 2 days and showed comparable wound-healing rates within 2 weeks with those of Spongostan®. In conclusion, PEI-PVP hydrogels are suitable for use as socket-dressing materials, and the release of local anaesthesia from PEI-PVP hydrogels can be sustained for a desirable period of time to prevent pain after a tooth extraction.
| Original language | English |
|---|---|
| Pages (from-to) | 2171-2184 |
| Number of pages | 14 |
| Journal | Journal of Biomaterials Science, Polymer Edition |
| Volume | 23 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - 2012 |
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Keywords
- Hydrogel
- Poly(vinyl pyrrolidone)
- Polyethyleneimine
- Socket filler
ASJC Scopus subject areas
- Biophysics
- Biomaterials
- Bioengineering
- Biomedical Engineering
Cite this
Development of swellable local implants of a polyethyleneimine-poly(vinyl pyrrolidone) (PEI-PVP) hydrogel as a socket filler. / Chang, Ching Wen; Ho, Hsiu O.; Lo, Yi June; Lee, Sheng Yang; Yang, You Ren; Sheu, Ming Thau.
In: Journal of Biomaterials Science, Polymer Edition, Vol. 23, No. 17, 2012, p. 2171-2184.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development of swellable local implants of a polyethyleneimine-poly(vinyl pyrrolidone) (PEI-PVP) hydrogel as a socket filler
AU - Chang, Ching Wen
AU - Ho, Hsiu O.
AU - Lo, Yi June
AU - Lee, Sheng Yang
AU - Yang, You Ren
AU - Sheu, Ming Thau
PY - 2012
Y1 - 2012
N2 - In this study, hydrogels composed of polyethyleneimine (PEI) and poly(vinyl pyrrolidone) K90 (PVP) cross-linked with various concentrations (0, 0.125, 0.25 and 0.5%) of glutaraldehyde were evaluated as a hydrogel filler for the local delivery of lidocaine after tooth extraction. The drug-release kinetics, swellability, cy-totoxicity and wound healing after tooth extraction of these non-cross-linked and cross-linked PEI-PVP hydrogels were examined in male beagles and compared to values using Spongostan®. Results demonstrated that the extent of cross-linking influenced the swelling of the resulting hydrogel, but the drug-release rates were similar. No significant changes were observed in gingival fibroblasts in contact with the PEI- PVP hydrogels or Spongostan®. In the in vivo study, PEI-PVP hydrogels showed good retention in the socket for 2 days and showed comparable wound-healing rates within 2 weeks with those of Spongostan®. In conclusion, PEI-PVP hydrogels are suitable for use as socket-dressing materials, and the release of local anaesthesia from PEI-PVP hydrogels can be sustained for a desirable period of time to prevent pain after a tooth extraction.
AB - In this study, hydrogels composed of polyethyleneimine (PEI) and poly(vinyl pyrrolidone) K90 (PVP) cross-linked with various concentrations (0, 0.125, 0.25 and 0.5%) of glutaraldehyde were evaluated as a hydrogel filler for the local delivery of lidocaine after tooth extraction. The drug-release kinetics, swellability, cy-totoxicity and wound healing after tooth extraction of these non-cross-linked and cross-linked PEI-PVP hydrogels were examined in male beagles and compared to values using Spongostan®. Results demonstrated that the extent of cross-linking influenced the swelling of the resulting hydrogel, but the drug-release rates were similar. No significant changes were observed in gingival fibroblasts in contact with the PEI- PVP hydrogels or Spongostan®. In the in vivo study, PEI-PVP hydrogels showed good retention in the socket for 2 days and showed comparable wound-healing rates within 2 weeks with those of Spongostan®. In conclusion, PEI-PVP hydrogels are suitable for use as socket-dressing materials, and the release of local anaesthesia from PEI-PVP hydrogels can be sustained for a desirable period of time to prevent pain after a tooth extraction.
KW - Hydrogel
KW - Poly(vinyl pyrrolidone)
KW - Polyethyleneimine
KW - Socket filler
UR - http://www.scopus.com/inward/record.url?scp=84867199615&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867199615&partnerID=8YFLogxK
U2 - 10.1163/092050611X611684
DO - 10.1163/092050611X611684
M3 - Article
C2 - 22127291
AN - SCOPUS:84867199615
VL - 23
SP - 2171
EP - 2184
JO - Journal of Biomaterials Science, Polymer Edition
JF - Journal of Biomaterials Science, Polymer Edition
SN - 0920-5063
IS - 17
ER -