Development of NTU standard Chinese brain template

Morphologic and functional comparison with MNI template using magnetic resonance imaging

Tun Jao, Chun Yuan Chang, Chia Wei Li, Der Yow Chen, Edzer Wu, Chang Wei Wu, Chi Hsuan Tsou, Chien Chang Ho, Jyh Horng Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

Background and Purpose: The brain structure mismatch between western and eastern people may lead to an inappropriate interpretation of neurocognitive studies. To minimize this interracial misinterpretation, we developed the National Taiwan University Chinese Brain Template (NTU-CBT). Methods: 102 (M/F=55/47) healthy Chinese subjects were recruited and received 3T MR brain scans. The template development processes were based on the construction process of Montreal Neurological Institute (MNI) template. Further pilot functional magnetic resonance imaging (fMRI) studies with blocked design visual stimulation and foot tapping task were performed on 3 volunteers and applied to both MNI template and NTU-CBT for analyses. Results: 7 subjects were excluded due to motion artifacts. The average brain size of 95 (M/F=50/45) subjects was 16.0 cm in length, 13.9 cm in width and 11.3 cm in height, which was 88.9%, 97.9% and 84.3% of the size of MNI template, respectively. Maximum dimensional differences came from the height of superior brain and the length of posterior brain. The average activation voxel volume of the fMRI studies applying to NTU-CBT was 80.7% of that to MNI template in visual stimulation, and 72.8% in foot tapping task. Noticeable mismatches were noted between interpolating original data to NTU-CBT and MNI template. Conclusions: Morphologic differences between MNI template and NTU-CBT do lead to spatial mismatch in functional studies, especially at cortical regions of superior and posterior brain. With the development of NTU-CBT, we look forward to more accurate interpretation in neurocognitive studies for Chinese subjects.

Original languageEnglish
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationEngineering the Future of Biomedicine, EMBC 2009
PublisherIEEE Computer Society
Pages4779-4782
Number of pages4
ISBN (Print)9781424432967
DOIs
Publication statusPublished - Jan 1 2009
Externally publishedYes
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Conference

Conference31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

Fingerprint

Magnetic resonance
Brain
Magnetic Resonance Imaging
Imaging techniques
Taiwan
Photic Stimulation
Foot
Artifacts
Volunteers
Healthy Volunteers
Chemical activation

Keywords

  • Atlas
  • Brain template
  • Functional Magnetic Resonance Imaging (fMRI)
  • MNI template
  • Morphometric analysis
  • NTU-CBT

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

Cite this

Jao, T., Chang, C. Y., Li, C. W., Chen, D. Y., Wu, E., Wu, C. W., ... Chen, J. H. (2009). Development of NTU standard Chinese brain template: Morphologic and functional comparison with MNI template using magnetic resonance imaging. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 4779-4782). [5334211] IEEE Computer Society. https://doi.org/10.1109/IEMBS.2009.5334211

Development of NTU standard Chinese brain template : Morphologic and functional comparison with MNI template using magnetic resonance imaging. / Jao, Tun; Chang, Chun Yuan; Li, Chia Wei; Chen, Der Yow; Wu, Edzer; Wu, Chang Wei; Tsou, Chi Hsuan; Ho, Chien Chang; Chen, Jyh Horng.

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, 2009. p. 4779-4782 5334211.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Jao, T, Chang, CY, Li, CW, Chen, DY, Wu, E, Wu, CW, Tsou, CH, Ho, CC & Chen, JH 2009, Development of NTU standard Chinese brain template: Morphologic and functional comparison with MNI template using magnetic resonance imaging. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5334211, IEEE Computer Society, pp. 4779-4782, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5334211
Jao T, Chang CY, Li CW, Chen DY, Wu E, Wu CW et al. Development of NTU standard Chinese brain template: Morphologic and functional comparison with MNI template using magnetic resonance imaging. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society. 2009. p. 4779-4782. 5334211 https://doi.org/10.1109/IEMBS.2009.5334211
Jao, Tun ; Chang, Chun Yuan ; Li, Chia Wei ; Chen, Der Yow ; Wu, Edzer ; Wu, Chang Wei ; Tsou, Chi Hsuan ; Ho, Chien Chang ; Chen, Jyh Horng. / Development of NTU standard Chinese brain template : Morphologic and functional comparison with MNI template using magnetic resonance imaging. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, 2009. pp. 4779-4782
@inproceedings{020a858e595d4b3eab1a5f759ca75cef,
title = "Development of NTU standard Chinese brain template: Morphologic and functional comparison with MNI template using magnetic resonance imaging",
abstract = "Background and Purpose: The brain structure mismatch between western and eastern people may lead to an inappropriate interpretation of neurocognitive studies. To minimize this interracial misinterpretation, we developed the National Taiwan University Chinese Brain Template (NTU-CBT). Methods: 102 (M/F=55/47) healthy Chinese subjects were recruited and received 3T MR brain scans. The template development processes were based on the construction process of Montreal Neurological Institute (MNI) template. Further pilot functional magnetic resonance imaging (fMRI) studies with blocked design visual stimulation and foot tapping task were performed on 3 volunteers and applied to both MNI template and NTU-CBT for analyses. Results: 7 subjects were excluded due to motion artifacts. The average brain size of 95 (M/F=50/45) subjects was 16.0 cm in length, 13.9 cm in width and 11.3 cm in height, which was 88.9{\%}, 97.9{\%} and 84.3{\%} of the size of MNI template, respectively. Maximum dimensional differences came from the height of superior brain and the length of posterior brain. The average activation voxel volume of the fMRI studies applying to NTU-CBT was 80.7{\%} of that to MNI template in visual stimulation, and 72.8{\%} in foot tapping task. Noticeable mismatches were noted between interpolating original data to NTU-CBT and MNI template. Conclusions: Morphologic differences between MNI template and NTU-CBT do lead to spatial mismatch in functional studies, especially at cortical regions of superior and posterior brain. With the development of NTU-CBT, we look forward to more accurate interpretation in neurocognitive studies for Chinese subjects.",
keywords = "Atlas, Brain template, Functional Magnetic Resonance Imaging (fMRI), MNI template, Morphometric analysis, NTU-CBT",
author = "Tun Jao and Chang, {Chun Yuan} and Li, {Chia Wei} and Chen, {Der Yow} and Edzer Wu and Wu, {Chang Wei} and Tsou, {Chi Hsuan} and Ho, {Chien Chang} and Chen, {Jyh Horng}",
year = "2009",
month = "1",
day = "1",
doi = "10.1109/IEMBS.2009.5334211",
language = "English",
isbn = "9781424432967",
pages = "4779--4782",
booktitle = "Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society",
publisher = "IEEE Computer Society",
address = "United States",

}

TY - GEN

T1 - Development of NTU standard Chinese brain template

T2 - Morphologic and functional comparison with MNI template using magnetic resonance imaging

AU - Jao, Tun

AU - Chang, Chun Yuan

AU - Li, Chia Wei

AU - Chen, Der Yow

AU - Wu, Edzer

AU - Wu, Chang Wei

AU - Tsou, Chi Hsuan

AU - Ho, Chien Chang

AU - Chen, Jyh Horng

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Background and Purpose: The brain structure mismatch between western and eastern people may lead to an inappropriate interpretation of neurocognitive studies. To minimize this interracial misinterpretation, we developed the National Taiwan University Chinese Brain Template (NTU-CBT). Methods: 102 (M/F=55/47) healthy Chinese subjects were recruited and received 3T MR brain scans. The template development processes were based on the construction process of Montreal Neurological Institute (MNI) template. Further pilot functional magnetic resonance imaging (fMRI) studies with blocked design visual stimulation and foot tapping task were performed on 3 volunteers and applied to both MNI template and NTU-CBT for analyses. Results: 7 subjects were excluded due to motion artifacts. The average brain size of 95 (M/F=50/45) subjects was 16.0 cm in length, 13.9 cm in width and 11.3 cm in height, which was 88.9%, 97.9% and 84.3% of the size of MNI template, respectively. Maximum dimensional differences came from the height of superior brain and the length of posterior brain. The average activation voxel volume of the fMRI studies applying to NTU-CBT was 80.7% of that to MNI template in visual stimulation, and 72.8% in foot tapping task. Noticeable mismatches were noted between interpolating original data to NTU-CBT and MNI template. Conclusions: Morphologic differences between MNI template and NTU-CBT do lead to spatial mismatch in functional studies, especially at cortical regions of superior and posterior brain. With the development of NTU-CBT, we look forward to more accurate interpretation in neurocognitive studies for Chinese subjects.

AB - Background and Purpose: The brain structure mismatch between western and eastern people may lead to an inappropriate interpretation of neurocognitive studies. To minimize this interracial misinterpretation, we developed the National Taiwan University Chinese Brain Template (NTU-CBT). Methods: 102 (M/F=55/47) healthy Chinese subjects were recruited and received 3T MR brain scans. The template development processes were based on the construction process of Montreal Neurological Institute (MNI) template. Further pilot functional magnetic resonance imaging (fMRI) studies with blocked design visual stimulation and foot tapping task were performed on 3 volunteers and applied to both MNI template and NTU-CBT for analyses. Results: 7 subjects were excluded due to motion artifacts. The average brain size of 95 (M/F=50/45) subjects was 16.0 cm in length, 13.9 cm in width and 11.3 cm in height, which was 88.9%, 97.9% and 84.3% of the size of MNI template, respectively. Maximum dimensional differences came from the height of superior brain and the length of posterior brain. The average activation voxel volume of the fMRI studies applying to NTU-CBT was 80.7% of that to MNI template in visual stimulation, and 72.8% in foot tapping task. Noticeable mismatches were noted between interpolating original data to NTU-CBT and MNI template. Conclusions: Morphologic differences between MNI template and NTU-CBT do lead to spatial mismatch in functional studies, especially at cortical regions of superior and posterior brain. With the development of NTU-CBT, we look forward to more accurate interpretation in neurocognitive studies for Chinese subjects.

KW - Atlas

KW - Brain template

KW - Functional Magnetic Resonance Imaging (fMRI)

KW - MNI template

KW - Morphometric analysis

KW - NTU-CBT

UR - http://www.scopus.com/inward/record.url?scp=77951006572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951006572&partnerID=8YFLogxK

U2 - 10.1109/IEMBS.2009.5334211

DO - 10.1109/IEMBS.2009.5334211

M3 - Conference contribution

SN - 9781424432967

SP - 4779

EP - 4782

BT - Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society

PB - IEEE Computer Society

ER -