Development of multifocal duodenal erosions after Anti-Helicobacter pylori triple therapy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background and Purpose: Anti-Helicobacter pylori triple therapy is effective for healing duodenal ulcer (DU) diseases and reducing disease recurrence. However, multifocal duodenal erosions or shallow ulcers may develop after triple therapy. The purpose of this study was to investigate the incidence and outcome of duodenal erosions that developed after triple therapy. Methods: A total of 106 Taiwanese with active DU and with H. pylori infection were enrolled in this study. All patients received anti-H. pylori triple therapy (i.e., 2 weeks of antimicrobial agents combined with treatment for 4 to 6 weeks with acid suppression agents). Follow-up endoscopy was performed immediately after stopping treatment. The incidence of multifocal erosions or shallow ulcers over the bulb and/or second portion of the duodenum was studied. Additional acid suppression agent was given for 4 weeks whenever duodenal erosions or shallow ulcers were found. Results: Out of 106 patients, 11 (10.4%) were found to have multifocal duodenal erosions and/or shallow ulcers on the duodenal bulb and/or second portion of the duodenum at the end of treatment. Ten of the 11 patients with newly developed erosions had healed DU in the S1 or S2 stage, and all 11 had successful H. pylori eradication. The duodenal erosions and/or shallow ulcers of these 11 patients were healed after an additional 4 weeks of histamine-2-receptor antagonist therapy. Conclusions: Multifocal duodenal erosions and/or shallow ulcers were noted in around 10% of Taiwanese DU patients who received anti-H. pylori triple therapy. An additional 4 weeks therapy with acid suppression agents healed these lesions.

Original languageEnglish
Pages (from-to)840-844
Number of pages5
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume102
Issue number12
Publication statusPublished - Dec 2003

Fingerprint

Helicobacter pylori
Duodenal Ulcer
Ulcer
Therapeutics
Duodenum
Acids
Duodenal Diseases
Histamine Receptors
Incidence
Helicobacter Infections
Anti-Infective Agents
Endoscopy
Recurrence

Keywords

  • Anti-ulcer therapy
  • Duodenal ulcer
  • Duodenum
  • Helicobacter pylori
  • Pathology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{43b45d96a81747898fa1a2e7b73892fd,
title = "Development of multifocal duodenal erosions after Anti-Helicobacter pylori triple therapy",
abstract = "Background and Purpose: Anti-Helicobacter pylori triple therapy is effective for healing duodenal ulcer (DU) diseases and reducing disease recurrence. However, multifocal duodenal erosions or shallow ulcers may develop after triple therapy. The purpose of this study was to investigate the incidence and outcome of duodenal erosions that developed after triple therapy. Methods: A total of 106 Taiwanese with active DU and with H. pylori infection were enrolled in this study. All patients received anti-H. pylori triple therapy (i.e., 2 weeks of antimicrobial agents combined with treatment for 4 to 6 weeks with acid suppression agents). Follow-up endoscopy was performed immediately after stopping treatment. The incidence of multifocal erosions or shallow ulcers over the bulb and/or second portion of the duodenum was studied. Additional acid suppression agent was given for 4 weeks whenever duodenal erosions or shallow ulcers were found. Results: Out of 106 patients, 11 (10.4{\%}) were found to have multifocal duodenal erosions and/or shallow ulcers on the duodenal bulb and/or second portion of the duodenum at the end of treatment. Ten of the 11 patients with newly developed erosions had healed DU in the S1 or S2 stage, and all 11 had successful H. pylori eradication. The duodenal erosions and/or shallow ulcers of these 11 patients were healed after an additional 4 weeks of histamine-2-receptor antagonist therapy. Conclusions: Multifocal duodenal erosions and/or shallow ulcers were noted in around 10{\%} of Taiwanese DU patients who received anti-H. pylori triple therapy. An additional 4 weeks therapy with acid suppression agents healed these lesions.",
keywords = "Anti-ulcer therapy, Duodenal ulcer, Duodenum, Helicobacter pylori, Pathology",
author = "Chang, {Chun Chao} and Shiann Pan and Sheng-Hsuan Chen and Jean-Dean Liu and Lien, {Gi Shih} and Yeong-Shan Cheng",
year = "2003",
month = "12",
language = "English",
volume = "102",
pages = "840--844",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Elsevier Science Publishers B.V.",
number = "12",

}

TY - JOUR

T1 - Development of multifocal duodenal erosions after Anti-Helicobacter pylori triple therapy

AU - Chang, Chun Chao

AU - Pan, Shiann

AU - Chen, Sheng-Hsuan

AU - Liu, Jean-Dean

AU - Lien, Gi Shih

AU - Cheng, Yeong-Shan

PY - 2003/12

Y1 - 2003/12

N2 - Background and Purpose: Anti-Helicobacter pylori triple therapy is effective for healing duodenal ulcer (DU) diseases and reducing disease recurrence. However, multifocal duodenal erosions or shallow ulcers may develop after triple therapy. The purpose of this study was to investigate the incidence and outcome of duodenal erosions that developed after triple therapy. Methods: A total of 106 Taiwanese with active DU and with H. pylori infection were enrolled in this study. All patients received anti-H. pylori triple therapy (i.e., 2 weeks of antimicrobial agents combined with treatment for 4 to 6 weeks with acid suppression agents). Follow-up endoscopy was performed immediately after stopping treatment. The incidence of multifocal erosions or shallow ulcers over the bulb and/or second portion of the duodenum was studied. Additional acid suppression agent was given for 4 weeks whenever duodenal erosions or shallow ulcers were found. Results: Out of 106 patients, 11 (10.4%) were found to have multifocal duodenal erosions and/or shallow ulcers on the duodenal bulb and/or second portion of the duodenum at the end of treatment. Ten of the 11 patients with newly developed erosions had healed DU in the S1 or S2 stage, and all 11 had successful H. pylori eradication. The duodenal erosions and/or shallow ulcers of these 11 patients were healed after an additional 4 weeks of histamine-2-receptor antagonist therapy. Conclusions: Multifocal duodenal erosions and/or shallow ulcers were noted in around 10% of Taiwanese DU patients who received anti-H. pylori triple therapy. An additional 4 weeks therapy with acid suppression agents healed these lesions.

AB - Background and Purpose: Anti-Helicobacter pylori triple therapy is effective for healing duodenal ulcer (DU) diseases and reducing disease recurrence. However, multifocal duodenal erosions or shallow ulcers may develop after triple therapy. The purpose of this study was to investigate the incidence and outcome of duodenal erosions that developed after triple therapy. Methods: A total of 106 Taiwanese with active DU and with H. pylori infection were enrolled in this study. All patients received anti-H. pylori triple therapy (i.e., 2 weeks of antimicrobial agents combined with treatment for 4 to 6 weeks with acid suppression agents). Follow-up endoscopy was performed immediately after stopping treatment. The incidence of multifocal erosions or shallow ulcers over the bulb and/or second portion of the duodenum was studied. Additional acid suppression agent was given for 4 weeks whenever duodenal erosions or shallow ulcers were found. Results: Out of 106 patients, 11 (10.4%) were found to have multifocal duodenal erosions and/or shallow ulcers on the duodenal bulb and/or second portion of the duodenum at the end of treatment. Ten of the 11 patients with newly developed erosions had healed DU in the S1 or S2 stage, and all 11 had successful H. pylori eradication. The duodenal erosions and/or shallow ulcers of these 11 patients were healed after an additional 4 weeks of histamine-2-receptor antagonist therapy. Conclusions: Multifocal duodenal erosions and/or shallow ulcers were noted in around 10% of Taiwanese DU patients who received anti-H. pylori triple therapy. An additional 4 weeks therapy with acid suppression agents healed these lesions.

KW - Anti-ulcer therapy

KW - Duodenal ulcer

KW - Duodenum

KW - Helicobacter pylori

KW - Pathology

UR - http://www.scopus.com/inward/record.url?scp=2342461143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2342461143&partnerID=8YFLogxK

M3 - Article

C2 - 14976562

AN - SCOPUS:2342461143

VL - 102

SP - 840

EP - 844

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

IS - 12

ER -