Abstract

Aim: This study aims to validate the anti-Helicobacter pylori efficacy of amoxicillin-loaded nanoparticles and nanogels with pH-responsive and site-specific drug release properties against H. pylori infection. Materials & methods: Genipin-crosslinked low molecular weight fucoidan/chitosan-N-arginine nanogels (FCSA) were prepared for targeted delivery of amoxicillin to the site of H. pylori infected AGS gastric epithelial cells. Results: The negatively charged nanogels (n-FCSA) adhered to H. pylori and exhibited pH-responsive drug release property to reduce cytotoxic effects in H. pylori infected AGS cells. Conclusion: These in vitro findings suggest that n-FCSA nanogels are potential carriers for H. pylori specific delivery of antibacterial agents, and provide the basis for further studies on the clinical use of the nanogels.

Original languageEnglish
Pages (from-to)1491-1510
Number of pages20
JournalNanomedicine
Volume12
Issue number12
DOIs
Publication statusPublished - Jun 1 2017

Fingerprint

Arginine
Chitosan
Helicobacter Infections
Helicobacter pylori
drug
Bactericides
Amoxicillin
Molecular weight
Nanoparticles
genipin
fucoidan
NanoGel
infection
Pharmaceutical Preparations
Stomach
Molecular Weight
Epithelial Cells
Anti-Bacterial Agents
nanoparticle
method

Keywords

  • antibacterial
  • chitosan
  • drug delivery
  • fucoidan
  • H. pylori
  • nanogels
  • nanoparticles

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Bioengineering
  • Biomedical Engineering
  • Development
  • Materials Science(all)

Cite this

Development of genipin-crosslinked fucoidan/chitosan-N-arginine nanogels for preventing Helicobacter infection. / Lin, Yu Hsin; Lu, Kun Ying; Tseng, Ching Li; Wu, Jui Yu; Chen, Chien Ho; Mi, Fwu Long.

In: Nanomedicine, Vol. 12, No. 12, 01.06.2017, p. 1491-1510.

Research output: Contribution to journalArticle

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AU - Wu, Jui Yu

AU - Chen, Chien Ho

AU - Mi, Fwu Long

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AB - Aim: This study aims to validate the anti-Helicobacter pylori efficacy of amoxicillin-loaded nanoparticles and nanogels with pH-responsive and site-specific drug release properties against H. pylori infection. Materials & methods: Genipin-crosslinked low molecular weight fucoidan/chitosan-N-arginine nanogels (FCSA) were prepared for targeted delivery of amoxicillin to the site of H. pylori infected AGS gastric epithelial cells. Results: The negatively charged nanogels (n-FCSA) adhered to H. pylori and exhibited pH-responsive drug release property to reduce cytotoxic effects in H. pylori infected AGS cells. Conclusion: These in vitro findings suggest that n-FCSA nanogels are potential carriers for H. pylori specific delivery of antibacterial agents, and provide the basis for further studies on the clinical use of the nanogels.

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