Development of diabetic retinopathy after cataract surgery

Chi Juei Jeng, Yi Ting Hsieh, Chung May Yang, Chang Hao Yang, Cheng Li Lin, I. Jong Wang

Research output: Contribution to journalArticle

Abstract

This study explored whether cataract surgery precipitates diabetic retinopathy (DR) development in diabetic patients without previous DR. Patients with the diagnosis of type II diabetes but without DR were selected from the Longitudinal Health Insurance Database 2000. Patients who received cataract surgery between January 1, 2000, and December 31, 2010, were included in the case group, and the control group was matched to the case group by age, sex, and index year. The postoperative incidence rates of nonproliferative diabetic retinopathy (NPDR), proliferative diabetic retinopathy (PDR), and diabetic macular edema (DME) were the main outcomes studied and were adjusted by age, sex, comorbidities, and statin, fibrate, angiotensin-converting-enzyme inhibitor (ACEI), oral hypoglycemic agents (OHA), and insulin use. In our cohort, patients who had dyslipidemia and used statins were more likely to undergo cataract surgery. Among diabetic patients without previous DR, patients receiving cataract surgery had a higher risk of NDPR development (adjusted hazard ratio = 1.48, 95% confidence interval = 1.15–1.91). No statistical difference was observed in PDR or DME development between operative and nonoperative groups. In additional stratified analyses, female sex, older age, comorbidities, surgery within 5 years, statin, ACEI, OHA, and insulin use increased the risk of NPDR development. In an adjusted Cox regression model, cataract surgery, OHA and insulin use were found to be risk factors for NPDR development. Cataract surgery with complications increased post-operative risks for NPDR were even higher, and the significant influence from cataract surgery persisted 5 years after surgery.

Original languageEnglish
Article numbere0202347
JournalPLoS One
Volume13
Issue number8
DOIs
Publication statusPublished - Aug 1 2018

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diabetic retinopathy
cataract
Diabetic Retinopathy
Cataract
Surgery
surgery
Hydroxymethylglutaryl-CoA Reductase Inhibitors
hypoglycemic agents
Hypoglycemic Agents
mouth
insulin
Macular Edema
Insulin
Angiotensin-Converting Enzyme Inhibitors
edema
Comorbidity
gender
Health insurance
Fibric Acids
health insurance

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Development of diabetic retinopathy after cataract surgery. / Jeng, Chi Juei; Hsieh, Yi Ting; Yang, Chung May; Yang, Chang Hao; Lin, Cheng Li; Wang, I. Jong.

In: PLoS One, Vol. 13, No. 8, e0202347, 01.08.2018.

Research output: Contribution to journalArticle

Jeng, Chi Juei ; Hsieh, Yi Ting ; Yang, Chung May ; Yang, Chang Hao ; Lin, Cheng Li ; Wang, I. Jong. / Development of diabetic retinopathy after cataract surgery. In: PLoS One. 2018 ; Vol. 13, No. 8.
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