Development of antiviral agents for enteroviruses

Tzu Chun Chen, Kuo Feng Weng, Shih Cheng Chang, Jing Yi Lin, Peng Nien Huang, Shin Ru Shih

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)

Abstract

Enteroviruses (EVs) are common human pathogens that are associated with numerous disease symptoms in many organ systems of the body. Although EV infections commonly cause mild or non-symptomatic illness, some of them are associated with severe diseases such as CNS complications. The current absence of effective vaccines for most viral infection and no available antiviral drugs for the treatment of EVs highlight the urgency and significance of developing antiviral agents. Several key steps in the viral life cycle are potential targets for blocking viral replication. This article reviews recent studies of antiviral developments for EVs based on various molecular targets that interrupt viral attachment, viral translation, polyprotein processing and RNA replication.

Original languageEnglish
Pages (from-to)1169-1173
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume62
Issue number6
DOIs
Publication statusPublished - 2008
Externally publishedYes

Keywords

  • 5′ untranslated region
  • Capsid proteins
  • Viral proteases
  • Viral RNA replication

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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