Abstract

A novel fiber-spray/mass spectrometry method using a piece of a porous hollow fiber is described. An adapter, fabricated by a 3D-printer, was designed to connect the fiber and a standard ESI (electrospray ionization) needle, in which a Taylor cone was formed and the resulting ions were detected by a mass spectrometer. Since a porous hollow fiber is usually used for microextraction, the so-called hollow fiber liquid-phase microextraction (HF-LPME) method, a new methodology that involves coupling HF-LPME and fiber-spray, was developed for the first time. We report herein on the design and testing of a microextraction kit. The kit consists of a centrifuge tube (reservoir for the sample solution) and a piece of a porous hollow fiber (for sample extraction). The kit was placed between the mass inlet and the ESI needle. Using the kit, analytes can be extracted from a very dilute solution and then evaporate and escape from the fiber surface. When they make contact with the ESI plume, which arises from the ESI needle tip, the molecules are ionized and then detected by a mass spectrometer. Using the setup, it was possible to improve the limit of detection after microextraction by ∼360-fold when 3,4-MDMA (3,4-methylenedioxymethamphetamine) was analyzed, and the limit of detection achieved was 2. ng/mL.

Original languageEnglish
JournalInternational Journal of Mass Spectrometry
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

Mass spectrometry
sprayers
mass spectroscopy
fibers
Fibers
Electrospray ionization
kits
hollow
needles
Needles
ionization
Mass spectrometers
mass spectrometers
liquid phases
3D printers
adapters
N-Methyl-3,4-methylenedioxyamphetamine
centrifuges
printers
Centrifuges

Keywords

  • 3,4-Methylenedioxymethamphetamine
  • Fiber-spray/mass spectrometry
  • Hollow fiber liquid phase microextraction

ASJC Scopus subject areas

  • Instrumentation
  • Condensed Matter Physics
  • Spectroscopy
  • Physical and Theoretical Chemistry

Cite this

Development of an on-line microextraction method for use in fiber-spray/mass spectrometry. / Liou, Yea Wenn; Wang, Jian Siang; Chen, Chien Chung; Lin, Cheng Huang.

In: International Journal of Mass Spectrometry, 2017.

Research output: Contribution to journalArticle

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