Development of a surface-functionalized titanium implant for promoting osseointegration: Surface characteristics, hemocompatibility, and in vivo evaluation

Ping Jen Hou, Syamsiah Syam, Wen Chien Lan, Keng Liang Ou, Bai Hung Huang, Ka Chun Chan, Chi Hsun Tsai, Takashi Saito, Chung Ming Liu, Hsin Hua Chou, Yueh Tzu Huang, Fang Yu Fan

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to evaluate the impact of surface-modified biomedical titanium (Ti) dental implant on osseointegration. The surfaces were modified using an innovative dip-coating technique (IDCT; sandblasted, large-grit, and acid-etched, then followed by coating with the modified pluronic F127 biodegradable polymer). The surface morphology and hemocompatibility evaluations were investigated by field-emission scanning electron microscopy, while the contact analysis was observed by goniometer. The IDCT-modified Ti implant was also implanted in patients with missing teeth by single-stage surgical procedure then observed immediately and again four months after placement by cone-beam computerized tomography (CBCT) imaging. It was found that the IDCT-modified Ti implant was rougher than the dental implant without surface modification. Contact angle analysis showed the IDCT-modified Ti implant was lower than the dental implant without surface modification. The hemocompatibility evaluations showed greater red blood cell aggregation and fibrin filament formation on the IDCT-modified Ti implant. The radiographic and CBCT image displayed new bone formation at four months after the IDCT-modified Ti implant placement. Therefore, this study suggests that the IDCT-modified Ti dental implant has great potential to accelerate osseointegration.

Original languageEnglish
Article number8582
Pages (from-to)1-10
Number of pages10
JournalApplied Sciences (Switzerland)
Volume10
Issue number23
DOIs
Publication statusPublished - Dec 1 2020

Keywords

  • Biodegradable polymer
  • Dental implant
  • Dip-coating
  • Osseointegration

ASJC Scopus subject areas

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

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