Development of a second clonally discrete Burkitt's lymphoma in a human immunodeficiency virus-positive homosexual patient

F. Barriga, J. Whang-Peng, E. Lee, C. Morrow, E. Jaffe, J. Cossman, I. T. Magrath

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We have studied, at a molecular level, two small non-cleaved cell malignant lymphomas (Burkitt's type) that were separated by a disease-free interval of 3 years in a patient infected with the human immunodeficiency virus (HIV). The late occurrence of the apparent relapse suggested that the second lymphoma might be caused by a separate malignant transformation in a discrete clone of B cells. Although both tumors expressed the same immunologic surface markers (μk) and carried the same t(8;14) translocation, Southern blot analysis of DNA from each tumor, using specific restriction endonucleases and probes to the c-myc and the immunoglobulin heavy chain loci, demonstrated that the chromosomal breakpoints relevant to the translocations differed between the tumors. This was corroborated by analysis of the immunoglobulin light-chain rearrangements in the two tumors. These observations indicate that the second tumor was not a recurrence of the first but represented the malignant transformation of a different clone of B cells. Thus late relapses of certain malignancies in individuals at high risk may be caused by the malignant transformation of discrete cell clones (i.e., induction of a new tumor).

Original languageEnglish
Pages (from-to)792-795
Number of pages4
JournalBlood
Volume72
Issue number2
Publication statusPublished - Jan 1 1988
Externally publishedYes

Fingerprint

Burkitt Lymphoma
Viruses
Tumors
HIV
Neoplasms
Clone Cells
Recurrence
Clone cells
Cells
Lymphoma
B-Lymphocytes
Immunoglobulin Light Chains
Immunoglobulin Heavy Chains
DNA Restriction Enzymes
Surface Antigens
Southern Blotting
Sexual Minorities
Non-Hodgkin's Lymphoma
DNA

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Barriga, F., Whang-Peng, J., Lee, E., Morrow, C., Jaffe, E., Cossman, J., & Magrath, I. T. (1988). Development of a second clonally discrete Burkitt's lymphoma in a human immunodeficiency virus-positive homosexual patient. Blood, 72(2), 792-795.

Development of a second clonally discrete Burkitt's lymphoma in a human immunodeficiency virus-positive homosexual patient. / Barriga, F.; Whang-Peng, J.; Lee, E.; Morrow, C.; Jaffe, E.; Cossman, J.; Magrath, I. T.

In: Blood, Vol. 72, No. 2, 01.01.1988, p. 792-795.

Research output: Contribution to journalArticle

Barriga, F, Whang-Peng, J, Lee, E, Morrow, C, Jaffe, E, Cossman, J & Magrath, IT 1988, 'Development of a second clonally discrete Burkitt's lymphoma in a human immunodeficiency virus-positive homosexual patient', Blood, vol. 72, no. 2, pp. 792-795.
Barriga, F. ; Whang-Peng, J. ; Lee, E. ; Morrow, C. ; Jaffe, E. ; Cossman, J. ; Magrath, I. T. / Development of a second clonally discrete Burkitt's lymphoma in a human immunodeficiency virus-positive homosexual patient. In: Blood. 1988 ; Vol. 72, No. 2. pp. 792-795.
@article{c1d623d0a56340898694512852e76706,
title = "Development of a second clonally discrete Burkitt's lymphoma in a human immunodeficiency virus-positive homosexual patient",
abstract = "We have studied, at a molecular level, two small non-cleaved cell malignant lymphomas (Burkitt's type) that were separated by a disease-free interval of 3 years in a patient infected with the human immunodeficiency virus (HIV). The late occurrence of the apparent relapse suggested that the second lymphoma might be caused by a separate malignant transformation in a discrete clone of B cells. Although both tumors expressed the same immunologic surface markers (μk) and carried the same t(8;14) translocation, Southern blot analysis of DNA from each tumor, using specific restriction endonucleases and probes to the c-myc and the immunoglobulin heavy chain loci, demonstrated that the chromosomal breakpoints relevant to the translocations differed between the tumors. This was corroborated by analysis of the immunoglobulin light-chain rearrangements in the two tumors. These observations indicate that the second tumor was not a recurrence of the first but represented the malignant transformation of a different clone of B cells. Thus late relapses of certain malignancies in individuals at high risk may be caused by the malignant transformation of discrete cell clones (i.e., induction of a new tumor).",
author = "F. Barriga and J. Whang-Peng and E. Lee and C. Morrow and E. Jaffe and J. Cossman and Magrath, {I. T.}",
year = "1988",
month = "1",
day = "1",
language = "English",
volume = "72",
pages = "792--795",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "2",

}

TY - JOUR

T1 - Development of a second clonally discrete Burkitt's lymphoma in a human immunodeficiency virus-positive homosexual patient

AU - Barriga, F.

AU - Whang-Peng, J.

AU - Lee, E.

AU - Morrow, C.

AU - Jaffe, E.

AU - Cossman, J.

AU - Magrath, I. T.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - We have studied, at a molecular level, two small non-cleaved cell malignant lymphomas (Burkitt's type) that were separated by a disease-free interval of 3 years in a patient infected with the human immunodeficiency virus (HIV). The late occurrence of the apparent relapse suggested that the second lymphoma might be caused by a separate malignant transformation in a discrete clone of B cells. Although both tumors expressed the same immunologic surface markers (μk) and carried the same t(8;14) translocation, Southern blot analysis of DNA from each tumor, using specific restriction endonucleases and probes to the c-myc and the immunoglobulin heavy chain loci, demonstrated that the chromosomal breakpoints relevant to the translocations differed between the tumors. This was corroborated by analysis of the immunoglobulin light-chain rearrangements in the two tumors. These observations indicate that the second tumor was not a recurrence of the first but represented the malignant transformation of a different clone of B cells. Thus late relapses of certain malignancies in individuals at high risk may be caused by the malignant transformation of discrete cell clones (i.e., induction of a new tumor).

AB - We have studied, at a molecular level, two small non-cleaved cell malignant lymphomas (Burkitt's type) that were separated by a disease-free interval of 3 years in a patient infected with the human immunodeficiency virus (HIV). The late occurrence of the apparent relapse suggested that the second lymphoma might be caused by a separate malignant transformation in a discrete clone of B cells. Although both tumors expressed the same immunologic surface markers (μk) and carried the same t(8;14) translocation, Southern blot analysis of DNA from each tumor, using specific restriction endonucleases and probes to the c-myc and the immunoglobulin heavy chain loci, demonstrated that the chromosomal breakpoints relevant to the translocations differed between the tumors. This was corroborated by analysis of the immunoglobulin light-chain rearrangements in the two tumors. These observations indicate that the second tumor was not a recurrence of the first but represented the malignant transformation of a different clone of B cells. Thus late relapses of certain malignancies in individuals at high risk may be caused by the malignant transformation of discrete cell clones (i.e., induction of a new tumor).

UR - http://www.scopus.com/inward/record.url?scp=0023813401&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023813401&partnerID=8YFLogxK

M3 - Article

C2 - 3401598

AN - SCOPUS:0023813401

VL - 72

SP - 792

EP - 795

JO - Blood

JF - Blood

SN - 0006-4971

IS - 2

ER -