Development of a prognostic nomogram for identifying those factors which influence the 2- and 5-year survival chances of Taiwanese women diagnosed with breast cancer

Y. P. Fan, C. L. Liu, I. J. Chiang, C. Y. Lin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Breast cancer is one of the main causes of death for women throughout the world. The objective of this study is to identify significant factors of patients and their tumours that can be used to predict a 5-year survival status for Asian women. Patients who had been diagnosed with invasive breast carcinoma and undergone mastectomy were selected (n= 1016). Patient characteristics and outcome variables were also retrieved. A nomogram was created and its performance was evaluated by calculating its discrimination (concordance index), calibration, and by subsequent internal validation. The median follow-up was 39 months and mean overall survival was 62.5 months. Independent predictors of overall survival included in the nomogram were age, tumour size, lymph node involvement, metastasis and oestrogen receptor status. The concordance index was 0.80 and the calibration was excellent with all observed outcomes within the 95% CI of each predicted survival probability. The nomogram model was developed to predict the probability of survival in patients with breast cancer and should be useful for counselling patients and establishing appropriate surveillance strategies for Asian women.

Original languageEnglish
Pages (from-to)620-626
Number of pages7
JournalEuropean Journal of Cancer Care
Volume20
Issue number5
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Nomograms
Breast Neoplasms
Survival
Calibration
Women's Rights
Mastectomy
Estrogen Receptors
Counseling
Cause of Death
Neoplasms
Lymph Nodes
Neoplasm Metastasis

Keywords

  • Breast cancer
  • Nomogram development
  • Prognostication
  • Risk factors
  • Survival chances
  • Taiwan

ASJC Scopus subject areas

  • Oncology

Cite this

Development of a prognostic nomogram for identifying those factors which influence the 2- and 5-year survival chances of Taiwanese women diagnosed with breast cancer. / Fan, Y. P.; Liu, C. L.; Chiang, I. J.; Lin, C. Y.

In: European Journal of Cancer Care, Vol. 20, No. 5, 09.2011, p. 620-626.

Research output: Contribution to journalArticle

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