Development of a new type of multifunctional fucoidan-based nanoparticles for anticancer drug delivery

Kun Ying Lu, Rou Li, Chun Hua Hsu, Cheng Wei Lin, Shen Chieh Chou, Min Lang Tsai, Fwu Long Mi

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Fucoidan, a sulfated marine polysaccharide, has many potential biological functions, including anticancer activity. Recently, fucoidan has been reported to target P-selectin expressed on metastatic cancer cells. Increasing research attention has been devoted to the developments of fucoidan-based nanomedicine. However, the application of traditional chitosan/fucoidan nanoparticles in anticancer drug delivery may be limited due to the deprotonation of chitosan at a pH greater than 6.5. In this study, a mutli-stimuli-responsive nanoparticle self-assembled by fucoidan and a cationic polypeptide (protamine) was developed, and their pH-/enzyme-responsive properties were characterized by circular dichroism (CD) spectroscopy, dynamic light scattering (DLS), and zeta potential analysis. Enzymatic digestion and acidic intracellular microenvironment (pH 4.5–5.5) in cancer cells triggered the release of an anticancer drug (doxorubicin) from the nanoparticles. The protamine/fucoidan complex nanoparticles with P-selectin mediated endocytosis, charge conversion and stimuli-tunable release properties showed an improved inhibitory effect against a metastatic breast cancer cell line (MDA-MB-231).

Original languageEnglish
Pages (from-to)410-420
Number of pages11
JournalCarbohydrate Polymers
Volume165
DOIs
Publication statusPublished - Jun 1 2017

Keywords

  • Drug delivery
  • Fucoidan
  • Metastatic cancer cells
  • Nanoparticles
  • P-selectin
  • Polypeptide

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Development of a new type of multifunctional fucoidan-based nanoparticles for anticancer drug delivery'. Together they form a unique fingerprint.

  • Cite this