Development of a growth-hormone-conjugated nanodiamond complex for cancer therapy

Hsueh Liang Chu, Hung Wei Chen, Shin Hua Tseng, Ming Hua Hsu, Li Ping Ho, Fu Hsuan Chou, Md Phd Hsing Yuan Li, Yu Chuan Chang, Pei Hsin Chen, Li Yun Tsai, Ching Chung Chou, Jyh Shin Chen, Tsai Mu Cheng, Chia Ching Chang

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10 Citations (Scopus)

Abstract

It is highly desirable to develop a therapeutic, observable nanoparticle complex for specific targeting in cancer therapy. Growth hormone (GH) and its antagonists have been explored as cancer cell-targeting molecules for both imaging and therapeutic applications. In this study, a low toxicity, biocompatible, therapeutic, and observable GH-nanoparticle complex for specifically targeting growth hormone receptor (GHR) in cancer cells was synthesized by conjugating GH with green fluorescence protein and carboxylated nanodiamond. Moreover, we have shown that this complex can be triggered by laser irradiation to create a "nanoblast" and induce cell death in the A549 non-small-cell lung cancer cell line via the apoptotic pathway. This laser-mediated, cancer-targeting platform can be widely used in cancer therapy. Small but significant: A new nanosurgery platform was formed using a laser-mediated, cancer-targeting nanodiamond (ND) complex. Laser irradiation at 532 nm created a nanoblast of the ND complex and induced cell death within a growth-hormone-receptor-containing lung cancer cell line.

Original languageEnglish
Pages (from-to)1023-1029
Number of pages7
JournalChemMedChem
Volume9
Issue number5
DOIs
Publication statusPublished - 2014

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Keywords

  • A549 lung cancer cells
  • apoptosis
  • lasers
  • nanodiamond complexes
  • recombinant growth hormones

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry
  • Molecular Medicine
  • Medicine(all)

Cite this

Chu, H. L., Chen, H. W., Tseng, S. H., Hsu, M. H., Ho, L. P., Chou, F. H., Li, M. P. H. Y., Chang, Y. C., Chen, P. H., Tsai, L. Y., Chou, C. C., Chen, J. S., Cheng, T. M., & Chang, C. C. (2014). Development of a growth-hormone-conjugated nanodiamond complex for cancer therapy. ChemMedChem, 9(5), 1023-1029. https://doi.org/10.1002/cmdc.201300541