Abstract

In this study, the chitosan-polyglutamate hydrogel was developed as injectable polyelectrolyte complex (PEC) scaffold for bone regeneration. In practice, oppositely charged polyelectrolytes were mixed using a static injection mixer, the gelation time was less than 1 min. The resorbable PEC scaffold can be in situ-formed as a scaffold for osteoblast ingrowth. The canine alveolar defect model was used to evaluate the efficacy of PEC implants. The PEC scaffold was highly effective in enhancing bone regeneration. Moreover, the addition of CaSO4·2H2O (CSD) to PEC scaffold can further enhance the early stage healing of bone regeneration.

Original languageEnglish
Pages (from-to)318-324
Number of pages7
JournalCarbohydrate Polymers
Volume85
Issue number2
DOIs
Publication statusPublished - May 6 2011

Fingerprint

Polyglutamic Acid
Chitosan
Polyelectrolytes
Scaffolds
Bone
Hydrogel
Osteoblasts
Gelation
Hydrogels
Defects

Keywords

  • Bone regeneration
  • Calcium sulfate dihydrate
  • Chitosan
  • Injectable scaffold
  • Polyelectrolyte complex
  • Polyglutamate acid

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Development of a chitosan-polyglutamate based injectable polyelectrolyte complex scaffold. / Wu, Hong Da; Yang, Jen Chang; Tsai, Tsuimin; Ji, Dain Yu; Chang, Wei Jen; Chen, Chien Chung; Lee, Sheng Yang.

In: Carbohydrate Polymers, Vol. 85, No. 2, 06.05.2011, p. 318-324.

Research output: Contribution to journalArticle

@article{27ff5d25ea8d45888bd16da61d36d1a1,
title = "Development of a chitosan-polyglutamate based injectable polyelectrolyte complex scaffold",
abstract = "In this study, the chitosan-polyglutamate hydrogel was developed as injectable polyelectrolyte complex (PEC) scaffold for bone regeneration. In practice, oppositely charged polyelectrolytes were mixed using a static injection mixer, the gelation time was less than 1 min. The resorbable PEC scaffold can be in situ-formed as a scaffold for osteoblast ingrowth. The canine alveolar defect model was used to evaluate the efficacy of PEC implants. The PEC scaffold was highly effective in enhancing bone regeneration. Moreover, the addition of CaSO4·2H2O (CSD) to PEC scaffold can further enhance the early stage healing of bone regeneration.",
keywords = "Bone regeneration, Calcium sulfate dihydrate, Chitosan, Injectable scaffold, Polyelectrolyte complex, Polyglutamate acid",
author = "Wu, {Hong Da} and Yang, {Jen Chang} and Tsuimin Tsai and Ji, {Dain Yu} and Chang, {Wei Jen} and Chen, {Chien Chung} and Lee, {Sheng Yang}",
year = "2011",
month = "5",
day = "6",
doi = "10.1016/j.carbpol.2011.02.024",
language = "English",
volume = "85",
pages = "318--324",
journal = "Carbohydrate Polymers",
issn = "0144-8617",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - Development of a chitosan-polyglutamate based injectable polyelectrolyte complex scaffold

AU - Wu, Hong Da

AU - Yang, Jen Chang

AU - Tsai, Tsuimin

AU - Ji, Dain Yu

AU - Chang, Wei Jen

AU - Chen, Chien Chung

AU - Lee, Sheng Yang

PY - 2011/5/6

Y1 - 2011/5/6

N2 - In this study, the chitosan-polyglutamate hydrogel was developed as injectable polyelectrolyte complex (PEC) scaffold for bone regeneration. In practice, oppositely charged polyelectrolytes were mixed using a static injection mixer, the gelation time was less than 1 min. The resorbable PEC scaffold can be in situ-formed as a scaffold for osteoblast ingrowth. The canine alveolar defect model was used to evaluate the efficacy of PEC implants. The PEC scaffold was highly effective in enhancing bone regeneration. Moreover, the addition of CaSO4·2H2O (CSD) to PEC scaffold can further enhance the early stage healing of bone regeneration.

AB - In this study, the chitosan-polyglutamate hydrogel was developed as injectable polyelectrolyte complex (PEC) scaffold for bone regeneration. In practice, oppositely charged polyelectrolytes were mixed using a static injection mixer, the gelation time was less than 1 min. The resorbable PEC scaffold can be in situ-formed as a scaffold for osteoblast ingrowth. The canine alveolar defect model was used to evaluate the efficacy of PEC implants. The PEC scaffold was highly effective in enhancing bone regeneration. Moreover, the addition of CaSO4·2H2O (CSD) to PEC scaffold can further enhance the early stage healing of bone regeneration.

KW - Bone regeneration

KW - Calcium sulfate dihydrate

KW - Chitosan

KW - Injectable scaffold

KW - Polyelectrolyte complex

KW - Polyglutamate acid

UR - http://www.scopus.com/inward/record.url?scp=79954862926&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954862926&partnerID=8YFLogxK

U2 - 10.1016/j.carbpol.2011.02.024

DO - 10.1016/j.carbpol.2011.02.024

M3 - Article

AN - SCOPUS:79954862926

VL - 85

SP - 318

EP - 324

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

IS - 2

ER -