Abstract

BACKGROUND: memory training is a potential intervention for retaining memory and reducing dementia risk in older adults with mild cognitive impairment (MCI).

OBJECTIVE: this study examined the effect of virtual interactive working memory training (VIMT) in older adults with MCI.

DESIGN: single-blind, two-arm parallel-group, randomised controlled design.

SETTING: retirement homes, institutions, and communities.

SUBJECTS: a total of 66 older adults with MCI were recruited (mean age: 78.5 ± 7.6 years).

METHODS: participants were randomly assigned to the experimental group (VIMT, n = 33) or active control group (n = 33). The VIMT program used the CogniPlus (includes four training modules). Both groups attended 45 min sessions 3 times per week, a total of 36 sessions. The primary outcome was working memory; secondary outcomes were immediate memory, delayed memory, subjective memory complaints and global cognitive function. All variables were measured at pre-test, post-test, and 3-month follow-up.

RESULTS: between group, the effect of working memory adjusted mean difference by 1.75 (95% CI: 0.56 to 2.94; P < 0.01) at post-test. The results were analysed by a generalised estimating equation, which indicated that VIMT group significantly improved working memory at post-test (P = 0.01) relative to the active control group.

CONCLUSIONS: the applied VIMT program can enable older adults with MCI to maintain their working memory and reduce the rate of cognitive deterioration.

TRIAL REGISTRATION: This trial was registered on ClinicalTrials.gov (no.: NCT02462135).

Original languageEnglish
Pages (from-to)519-525
Number of pages7
JournalAge and Ageing
Volume48
Issue number4
DOIs
Publication statusPublished - Jul 15 2019

Fingerprint

Short-Term Memory
Randomized Controlled Trials
Learning
Cognitive Dysfunction
Repression (Psychology)
Education
Control Groups
Retirement
Cognition
Dementia

Keywords

  • Memory training
  • mild cognitive impairment
  • working memory
  • randomised controlled trial
  • older people

Cite this

@article{50a6e1ecd5194a7986324f92dac8dd31,
title = "Development and effectiveness of virtual interactive working memory training for older people with mild cognitive impairment: a single-blind randomised controlled trial",
abstract = "BACKGROUND: memory training is a potential intervention for retaining memory and reducing dementia risk in older adults with mild cognitive impairment (MCI).OBJECTIVE: this study examined the effect of virtual interactive working memory training (VIMT) in older adults with MCI.DESIGN: single-blind, two-arm parallel-group, randomised controlled design.SETTING: retirement homes, institutions, and communities.SUBJECTS: a total of 66 older adults with MCI were recruited (mean age: 78.5 ± 7.6 years).METHODS: participants were randomly assigned to the experimental group (VIMT, n = 33) or active control group (n = 33). The VIMT program used the CogniPlus (includes four training modules). Both groups attended 45 min sessions 3 times per week, a total of 36 sessions. The primary outcome was working memory; secondary outcomes were immediate memory, delayed memory, subjective memory complaints and global cognitive function. All variables were measured at pre-test, post-test, and 3-month follow-up.RESULTS: between group, the effect of working memory adjusted mean difference by 1.75 (95{\%} CI: 0.56 to 2.94; P < 0.01) at post-test. The results were analysed by a generalised estimating equation, which indicated that VIMT group significantly improved working memory at post-test (P = 0.01) relative to the active control group.CONCLUSIONS: the applied VIMT program can enable older adults with MCI to maintain their working memory and reduce the rate of cognitive deterioration.TRIAL REGISTRATION: This trial was registered on ClinicalTrials.gov (no.: NCT02462135).",
keywords = "Memory training, mild cognitive impairment, working memory, randomised controlled trial, older people",
author = "Hui-Ling Yang and Hsin Chu and Ching-Chiu Kao and Huei-Ling Chiu and Ing-Jy Tseng and Philip Tseng and Kuei-Ru Chou",
note = "{\circledC} The Author(s) 2019. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.",
year = "2019",
month = "7",
day = "15",
doi = "10.1093/ageing/afz029",
language = "English",
volume = "48",
pages = "519--525",
journal = "Age and Ageing",
issn = "0002-0729",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Development and effectiveness of virtual interactive working memory training for older people with mild cognitive impairment

T2 - a single-blind randomised controlled trial

AU - Yang, Hui-Ling

AU - Chu, Hsin

AU - Kao, Ching-Chiu

AU - Chiu, Huei-Ling

AU - Tseng, Ing-Jy

AU - Tseng, Philip

AU - Chou, Kuei-Ru

N1 - © The Author(s) 2019. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.

PY - 2019/7/15

Y1 - 2019/7/15

N2 - BACKGROUND: memory training is a potential intervention for retaining memory and reducing dementia risk in older adults with mild cognitive impairment (MCI).OBJECTIVE: this study examined the effect of virtual interactive working memory training (VIMT) in older adults with MCI.DESIGN: single-blind, two-arm parallel-group, randomised controlled design.SETTING: retirement homes, institutions, and communities.SUBJECTS: a total of 66 older adults with MCI were recruited (mean age: 78.5 ± 7.6 years).METHODS: participants were randomly assigned to the experimental group (VIMT, n = 33) or active control group (n = 33). The VIMT program used the CogniPlus (includes four training modules). Both groups attended 45 min sessions 3 times per week, a total of 36 sessions. The primary outcome was working memory; secondary outcomes were immediate memory, delayed memory, subjective memory complaints and global cognitive function. All variables were measured at pre-test, post-test, and 3-month follow-up.RESULTS: between group, the effect of working memory adjusted mean difference by 1.75 (95% CI: 0.56 to 2.94; P < 0.01) at post-test. The results were analysed by a generalised estimating equation, which indicated that VIMT group significantly improved working memory at post-test (P = 0.01) relative to the active control group.CONCLUSIONS: the applied VIMT program can enable older adults with MCI to maintain their working memory and reduce the rate of cognitive deterioration.TRIAL REGISTRATION: This trial was registered on ClinicalTrials.gov (no.: NCT02462135).

AB - BACKGROUND: memory training is a potential intervention for retaining memory and reducing dementia risk in older adults with mild cognitive impairment (MCI).OBJECTIVE: this study examined the effect of virtual interactive working memory training (VIMT) in older adults with MCI.DESIGN: single-blind, two-arm parallel-group, randomised controlled design.SETTING: retirement homes, institutions, and communities.SUBJECTS: a total of 66 older adults with MCI were recruited (mean age: 78.5 ± 7.6 years).METHODS: participants were randomly assigned to the experimental group (VIMT, n = 33) or active control group (n = 33). The VIMT program used the CogniPlus (includes four training modules). Both groups attended 45 min sessions 3 times per week, a total of 36 sessions. The primary outcome was working memory; secondary outcomes were immediate memory, delayed memory, subjective memory complaints and global cognitive function. All variables were measured at pre-test, post-test, and 3-month follow-up.RESULTS: between group, the effect of working memory adjusted mean difference by 1.75 (95% CI: 0.56 to 2.94; P < 0.01) at post-test. The results were analysed by a generalised estimating equation, which indicated that VIMT group significantly improved working memory at post-test (P = 0.01) relative to the active control group.CONCLUSIONS: the applied VIMT program can enable older adults with MCI to maintain their working memory and reduce the rate of cognitive deterioration.TRIAL REGISTRATION: This trial was registered on ClinicalTrials.gov (no.: NCT02462135).

KW - Memory training

KW - mild cognitive impairment

KW - working memory

KW - randomised controlled trial

KW - older people

U2 - 10.1093/ageing/afz029

DO - 10.1093/ageing/afz029

M3 - Article

VL - 48

SP - 519

EP - 525

JO - Age and Ageing

JF - Age and Ageing

SN - 0002-0729

IS - 4

ER -