Development and Characterization of Lecithin-based Self-assembling Mixed Polymeric Micellar (saMPMs) Drug Delivery Systems for Curcumin

Ling Chun Chen, Yin-Chen Chen, Chia Yu Su, Wan Ping Wong, Ming-Thau Sheu, Hsiu-O Ho

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Self-assembling mixed polymeric micelles (saMPMs) were developed for overcoming major obstacles of poor bioavailability (BA) associated with curcumin delivery. Lecithin added was functioned to enlarge the hydrophobic core of MPMs providing greater solubilization capacity. Amphiphilic polymers (sodium deoxycholate [NaDOC], TPGS, CREMOPHOR, or a PLURONIC series) were examined for potentially self-assembling to form MPMs (saMPMs) with the addition of lecithin. Particle size, size distribution, encapsulation efficacy (E.E.), and drug loading (D.L.) of the mixed micelles were optimally studied for their influences on the physical stability and release of encapsulated drugs. Overall, curcumin:lecithin:NaDOC and curcumin:lecithin:PLURONIC P123 in ratios of 2:1:5 and 5:2:20, respectively, were optimally obtained with a particle size of < 200 nm, an E.E. of >80%, and a D.L. of >10%. The formulated system efficiently stabilized curcumin in phosphate-buffered saline (PBS) at room temperature or 4 °C and in fetal bovine serum or PBS at 37 °C and delayed the in vitro curcumin release. In vivo results further demonstrated that the slow release of curcumin from micelles and prolonged duration increased the curcumin BA followed oral and intravenous administrations in rats. Thus, lecithin-based saMPMs represent an effective curcumin delivery system, and enhancing BA of curcumin can enable its wide applications for treating human disorders.

Original languageEnglish
Article number37122
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - Nov 16 2016

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Curcumin
Lecithins
Drug Delivery Systems
Micelles
Biological Availability
Particle Size
Phosphates
Deoxycholic Acid
Pharmaceutical Preparations
Intravenous Administration
Oral Administration
Polymers
Temperature

ASJC Scopus subject areas

  • General

Cite this

Development and Characterization of Lecithin-based Self-assembling Mixed Polymeric Micellar (saMPMs) Drug Delivery Systems for Curcumin. / Chen, Ling Chun; Chen, Yin-Chen; Su, Chia Yu; Wong, Wan Ping; Sheu, Ming-Thau; Ho, Hsiu-O.

In: Scientific Reports, Vol. 6, 37122, 16.11.2016.

Research output: Contribution to journalArticle

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