Development and characterization of a bioinspired bone matrix with aligned nanocrystalline hydroxyapatite on collagen nanofibers

Hsi Chin Wu, Tzu Wei Wang, Jui Sheng Sun, Yi Hsuan Lee, Meng Han Shen, Zong Ruei Tsai, Chih Yu Chen, Horng Chaung Hsu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Various kinds of three-dimensional (3D) scaffolds have been designed to mimic the biological spontaneous bone formation characteristics by providing a suitable microenvironment for osteogenesis. In view of this, a natural bone-liked composite scaffold, which was combined with inorganic (hydroxyapatite, Hap) and organic (type I collagen, Col) phases, has been developed through a self-assembly process. This 3D porous scaffold consisting of a c-axis of Hap nanocrystals (nHap) aligning along Col fibrils arrangement is similar to natural bone architecture. A significant increase in mechanical strength and elastic modulus of nHap/Col scaffold is achieved through biomimetic mineralization process when compared with simple mixture of collagen and hydroxyapatite method. It is suggested that the self-organization of Hap and Col produced in vivo could also be achieved in vitro. The oriented nHap/Col composite not only possesses bone-like microstructure and adequate mechanical properties but also enhances the regeneration and reorganization abilities of bone tissue. These results demonstrated that biomimetic nHap/Col can be successfully reconstructed as a bone graft substitute in bone tissue engineering.

Original languageEnglish
Article number198
JournalMaterials
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 15 2016
Externally publishedYes

Fingerprint

Durapatite
Nanofibers
Hydroxyapatite
Collagen
Bone
Scaffolds
Biomimetics
Scaffolds (biology)
Composite materials
Collagen Type I
Tissue engineering
Grafts
Nanocrystals
Self assembly
Strength of materials
Elastic moduli
Tissue
Mechanical properties
Microstructure

Keywords

  • Biomimetic scaffold
  • Hydroxyapatite nanocrystal
  • Nanocomposite

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Wu, H. C., Wang, T. W., Sun, J. S., Lee, Y. H., Shen, M. H., Tsai, Z. R., ... Hsu, H. C. (2016). Development and characterization of a bioinspired bone matrix with aligned nanocrystalline hydroxyapatite on collagen nanofibers. Materials, 9(3), [198]. https://doi.org/10.3390/ma9030198

Development and characterization of a bioinspired bone matrix with aligned nanocrystalline hydroxyapatite on collagen nanofibers. / Wu, Hsi Chin; Wang, Tzu Wei; Sun, Jui Sheng; Lee, Yi Hsuan; Shen, Meng Han; Tsai, Zong Ruei; Chen, Chih Yu; Hsu, Horng Chaung.

In: Materials, Vol. 9, No. 3, 198, 15.03.2016.

Research output: Contribution to journalArticle

Wu, Hsi Chin ; Wang, Tzu Wei ; Sun, Jui Sheng ; Lee, Yi Hsuan ; Shen, Meng Han ; Tsai, Zong Ruei ; Chen, Chih Yu ; Hsu, Horng Chaung. / Development and characterization of a bioinspired bone matrix with aligned nanocrystalline hydroxyapatite on collagen nanofibers. In: Materials. 2016 ; Vol. 9, No. 3.
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