Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach

Tzu Sen Yang, Yujia Cui, Chien Ming Wu, Jem Mau Lo, Chi Shiun Chiang, Wun Yi Shu, Wei Ju Chung, Chung Shan Yu, Kuo Ning Chiang, Lan C. Hsu

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8 Citations (Scopus)

Abstract

Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.

Original languageEnglish
Pages (from-to)2791-2794
Number of pages4
JournalChemPhysChem
Volume10
Issue number16
DOIs
Publication statusPublished - Nov 9 2009

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Keywords

  • DNA
  • Drug design
  • Optical tweezers
  • Radiation therapy
  • Single-molecule studies

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Atomic and Molecular Physics, and Optics

Cite this

Yang, T. S., Cui, Y., Wu, C. M., Lo, J. M., Chiang, C. S., Shu, W. Y., Chung, W. J., Yu, C. S., Chiang, K. N., & Hsu, L. C. (2009). Determining the zero-force binding energetics of an intercalated DNA complex by a single-molecule approach. ChemPhysChem, 10(16), 2791-2794. https://doi.org/10.1002/cphc.200900435