TY - JOUR
T1 - Determination of deoxynivalenol in the urine of pregnant women in the UK
AU - Wells, Liz
AU - Hardie, Laura
AU - Williams, Courtney
AU - White, Kay
AU - Liu, Yunru
AU - De Santis, Barbara
AU - Debegnach, Francesca
AU - Moretti, Georgio
AU - Greetham, Stephanie
AU - Brera, Carlo
AU - Rigby, Alan
AU - Atkin, Stephen
AU - Sathyapalan, Thozhukat
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Deoxynivalenol (DON) is one of the most commonly occurring trichothecenes, produced mainly by Fusarium graminearum. Little is known about the effect of DON exposure or the levels of DON exposure that occur during pregnancy. The project aimed to provide data on levels of total DON and de-epoxi Deoxynivalenol (DOM-1) in pregnant human urine samples analysed by liquid chromatography-mass spectrometry (LC-MS). Morning urine samples were collected over two consecutive days from 42 volunteers and associated food consumption was recorded for the 24 h prior to the sample. Spearman’s rho non-parametric test for correlation was used to assess the data. Levels of DON did not differ significantly between day 1 (mean 29.7 ng/mL urine or 40.1 ng DON/mg creatinine) and day 2 (mean 28.7 ng/mL urine or 38.8 ng DON/mg creatinine ng/mL/day) urine samples. The only significant positive correlation was found between total ng DON/mg creatinine and parity (rho = 0.307, n = 42, p < 0.005 two-tailed) and total ng DON/mg creatinine with baked goods on day 1 (rho = 0.532, n = 42, p < 0.0005 two-tailed). This study provides data on the DON levels in pregnancy in this suburban population and reassurance that those levels are within acceptable limits.
AB - Deoxynivalenol (DON) is one of the most commonly occurring trichothecenes, produced mainly by Fusarium graminearum. Little is known about the effect of DON exposure or the levels of DON exposure that occur during pregnancy. The project aimed to provide data on levels of total DON and de-epoxi Deoxynivalenol (DOM-1) in pregnant human urine samples analysed by liquid chromatography-mass spectrometry (LC-MS). Morning urine samples were collected over two consecutive days from 42 volunteers and associated food consumption was recorded for the 24 h prior to the sample. Spearman’s rho non-parametric test for correlation was used to assess the data. Levels of DON did not differ significantly between day 1 (mean 29.7 ng/mL urine or 40.1 ng DON/mg creatinine) and day 2 (mean 28.7 ng/mL urine or 38.8 ng DON/mg creatinine ng/mL/day) urine samples. The only significant positive correlation was found between total ng DON/mg creatinine and parity (rho = 0.307, n = 42, p < 0.005 two-tailed) and total ng DON/mg creatinine with baked goods on day 1 (rho = 0.532, n = 42, p < 0.0005 two-tailed). This study provides data on the DON levels in pregnancy in this suburban population and reassurance that those levels are within acceptable limits.
KW - Deoxynivalenol
KW - Mycotoxins
KW - Pregnancy
KW - Vomitoxin
UR - http://www.scopus.com/inward/record.url?scp=84992707533&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84992707533&partnerID=8YFLogxK
U2 - 10.3390/toxins8110306
DO - 10.3390/toxins8110306
M3 - Article
C2 - 27792137
AN - SCOPUS:84992707533
VL - 8
JO - Toxins
JF - Toxins
SN - 2072-6651
IS - 11
M1 - 306
ER -