Determinants and characteristics of angle-closure disease in an elderly Chinese population

Yu Chieh Ko, Catherine J. Liu, Wen Ming Hsu, Ching Yu Cheng, Tung Mei Kuang, Pesus Chou

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Purpose: To determine factors associated with angle-closure disease, particularly in those with structural or functional damage to the eyes, in an elderly Chinese population. Methods: A total of 460 individuals aged over 72 years were recruited. The association of angle-closure diseases, including primary angle-closure suspect (PACS), primary angle-closure (PAC) and primary angle-closure glaucoma (PACG), with various systemic and ocular characteristics was evaluated using multivariate logistic regression analyses. Results: Of 374 phakic subjects, 199 (53.2%) had angle-closure disease, including 135 PACS, 46 PAC, and 18 PACG. The majority of those with untreated PACG (10/13, 76.9%) had presenting intraocular pressure (IOP) <20 mmHg. Independent risk factors for angle-closure disease were lower Van Herick grading, shallower central anterior chamber depth (ACD), and higher post-mydriatic IOP (all p <0.05). Central and peripheral ACD estimation correlated weakly, only 60.8% of angle-closure eyes had generalized narrowing of ACD as a Van Herick grading ≤2 and central ACD ≤ 2.83 mm. A criterion considering either central or peripheral ACD identified 91% of angle-closure eyes, including all PACG. A higher post-mydriatic IOP was associated with a diagnosis of PAC or PACG among angle-closure eyes (p = 0.002). Conclusion: Both central and peripheral ACD should be evaluated and shallowing of either one should be an indication for gonioscopic examination to maximize detection of angle-closure disease in elderly Chinese persons. PAC and PACG were associated with higher post-mydriatic IOP than PACS, although subjects with PACG frequently presented with normal IOP.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalOphthalmic Epidemiology
Issue number2
Publication statusPublished - Apr 1 2015


  • Angle-closure glaucoma
  • Anterior chamber depth
  • Elderly
  • Intraocular pressure
  • Mydriasis

ASJC Scopus subject areas

  • Ophthalmology
  • Epidemiology
  • Medicine(all)


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