Detection of teichoic acid antibodies in children with staphylococcal infections

Usa Thisyakorn, Sharon Shelton, Tzou Yien Lin, George H. McCracken, John D. Nelson

Research output: Contribution to journalArticle

Abstract

The presence of serum antibodies to teichoic acid was evaluated by gel diffusion and enzyme-linked immunosorbent assay in 14 patients with deep-seated staphylococcal infection, in 5 patients with superficial staphylococcal infections, in 10 patients with Gram-positive infections other than staphylococcal and in 12 age-matched, uninfected patients. Serum samples were obtained on admission and serially each week during hospitalization. Teichoic acid antibodies were detected by gel diffusion in only 5 of 14 patients with deep-seated staphylococcal infections, in 1 of 10 patients with other Gram-positive infections and in none of the other patients. With the enzyme-linked immunosorbent assay method all patients with deep-seated staphylococcal infections had concentrations of teichoic acid antibodies of 1:1600 or greater, and these titers were significantly larger than those in the other groups of patients. Using a titer of 1:3200 or greater as a diagnostic level in children with deep-seated Staphylococcus aureus infections, the sensitivity was 93% and the specificity was 89%. For all staphylococcal infections the sensitivity was 79% and the specificity was 96%.

Original languageEnglish
Pages (from-to)222-225
Number of pages4
JournalPediatric Infectious Disease
Volume3
Issue number3
Publication statusPublished - 1984
Externally publishedYes

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Teichoic Acids
Staphylococcal Infections
Antibodies
Gels
Enzyme-Linked Immunosorbent Assay
Infection
Serum
Staphylococcus aureus
Hospitalization

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)
  • Infectious Diseases

Cite this

Thisyakorn, U., Shelton, S., Lin, T. Y., McCracken, G. H., & Nelson, J. D. (1984). Detection of teichoic acid antibodies in children with staphylococcal infections. Pediatric Infectious Disease, 3(3), 222-225.

Detection of teichoic acid antibodies in children with staphylococcal infections. / Thisyakorn, Usa; Shelton, Sharon; Lin, Tzou Yien; McCracken, George H.; Nelson, John D.

In: Pediatric Infectious Disease, Vol. 3, No. 3, 1984, p. 222-225.

Research output: Contribution to journalArticle

Thisyakorn, U, Shelton, S, Lin, TY, McCracken, GH & Nelson, JD 1984, 'Detection of teichoic acid antibodies in children with staphylococcal infections', Pediatric Infectious Disease, vol. 3, no. 3, pp. 222-225.
Thisyakorn, Usa ; Shelton, Sharon ; Lin, Tzou Yien ; McCracken, George H. ; Nelson, John D. / Detection of teichoic acid antibodies in children with staphylococcal infections. In: Pediatric Infectious Disease. 1984 ; Vol. 3, No. 3. pp. 222-225.
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